Effect of Increased Daily Water Intake and Hydration on Health in Japanese Adults
Nakamura Y, Watanabe H, Tanaka A, Yasui M, Nishihira J, Murayama N
Nutrients · 32 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Japan Society for the Promotion of Science
- Grants
- Japan Society for the Promotion of Science (18H02606)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-04-23 · Nutrients · vol. 12 · issue 4 · p. 1191
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 60 citations · more than 93% of similar papers · 3.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Diet and metabolism studies · Thermoregulation and physiological responses · Dietary Effects on Health
- Keywords
- Bedtime, Medicine, Blood pressure, Body water, Vasopressin, Renal function, Internal medicine, Urine specific gravity, Urine, Blood urea nitrogen, Endocrinology, Animal science, Physiology, Body weight, Biology
- MeSH
- kidney, body water, humans, blood urea nitrogen, glomerular filtration rate, body temperature, blood pressure, drinking, aged, middle aged, female, male, nutritional physiological phenomena, healthy volunteers, biomarkers, gastrointestinal microbiome, organism hydration status, asian people
6 authors
From JP
- Yumi Nakamura · correspondingSuntory Foundation for Life Sciences; Suntory Global Innovation Center Ltd. (Japan)
- Hiroshi WatanabeSuntory Foundation for Life Sciences; Suntory Global Innovation Center Ltd. (Japan)
- Aiko TanakaHokkaido Information University
- Masato YasuiKeio University Hospital
- Jun NishihiraHokkaido Information University
- Norihito MurayamaSuntory Foundation for Life Sciences; Suntory Global Innovation Center Ltd. (Japan)
Abstract
Increased hydration is recommended as healthy habit with several merits. However, supportive data are sparse. To assess the efficacy of increased daily water intake, we tested the effect of water supplementation on biomarkers in blood, urine, and saliva. Twenty-four healthy Japanese men and 31 healthy Japanese women with fasting blood glucose levels ranging from 90-125 mg/dL were included. An open-label, two-arm, randomized controlled trial was conducted for 12 weeks. Two additional 550 mL bottles of water on top of habitual fluid intake were consumed in the intervention group. The subjects drank one bottle of water (550 mL) within 2 h of waking, and one bottle (550 mL) 2 h before bedtime. Subjects increased mean fluid intake from 1.3 L/day to 2.0 L/day, without changes in total energy intake. Total body water rate increased with associated water supplementation. There were no significant changes in fasting blood glucose and arginine vasopressin levels, but systolic blood pressure was significantly decreased in the intervention group. Furthermore, water supplementation increased body temperature, reduced blood urea nitrogen concentration, and suppressed estimated glomerular filtration rate reduction. Additionally, existence of an intestinal microbiome correlated with decreased systolic blood pressure and increased body temperature. Habitual water supplementation after waking up and before bedtime in healthy subjects with slightly elevated fasting blood glucose levels is not effective in lowering these levels. However, it represents a safe and promising intervention with the potential for lowering blood pressure, increasing body temperature, diluting blood waste materials, and protecting kidney function. Thus, increasing daily water intake could provide several health benefits.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.