Beneficial Effects of Time-Restricted Eating on Metabolic Diseases: A Systemic Review and Meta-Analysis
Moon S, Kang J, Kim SH, Chung HS, Kim YJ, Yu JM, Cho ST, Oh CM, Kim T
Nutrients · 180 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Gwangju Institute of Science and Technology
- Government
- National Research Foundation of Korea
- Grants
- National Research Foundation of Korea (2018R1A2B0002804); National Research Foundation of Korea (2016R1A6A3A04010466)
Based on 2 listed funder(s).
Publication
- Published
- 2020-04-29 · Nutrients · vol. 12 · issue 5 · p. 1267
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 233 citations · more than 99% of similar papers · 14.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 63 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Keywords
- Circadian rhythm, Medicine, Overweight, Internal medicine, Metabolic syndrome, Confidence interval, Glucose homeostasis, Endocrinology, Blood pressure, Meta-analysis, Obesity, Cochrane Library, Physiology, Cholesterol, Energy homeostasis, Gastroenterology, Insulin resistance
- MeSH
- humans, metabolic diseases, obesity, body weight, cholesterol, diet therapy, fasting, body composition, circadian rhythm, homeostasis, blood pressure, eating, time, overweight
9 authors
From KR
- Shinje MoonHallym University
- Jiseung KangGwangju Institute of Science and Technology
- Sang Hyun KimGwangju Institute of Science and Technology
- Hye Soo ChungHallym University
- Yoon Jung KimHallym University
- Jae Myung YuHallym University
Abstract
Various behavioral and physiological pathways follow a pre-determined, 24 hour cycle known as the circadian rhythm. Metabolic homeostasis is regulated by the circadian rhythm. Time-restricted eating (TRE) is a type of intermittent fasting based on the circadian rhythm. In this study, we aim to analyze systemically the effects of TRE on body weight, body composition, and other metabolic parameters. We reviewed articles from PubMed, EMBASE, and the Cochrane Library to identify clinical trials that compared TRE to a regular diet. We included 19 studies for meta-analysis. Participants following TRE showed significantly reduced body weight (mean difference (MD), -0.90; 95% confidence interval (CI): -1.71 to -0.10) and fat mass (MD: -1.58, 95% CI: -2.64 to -0.51), while preserving fat-free mass (MD, -0.24; 95% CI: -1.15 to 0.67). TRE also showed beneficial effects on cardiometabolic parameters such as blood pressure (systolic BP, MD, -3.07; 95% CI: -5.76 to -0.37), fasting glucose concentration (MD, -2.96; 95% CI, -5.60 to -0.33), and cholesterol profiles (triglycerides, MD: -11.60, 95% CI: -23.30 to -0.27). In conclusion, TRE is a promising therapeutic strategy for controlling weight and improving metabolic dysfunctions in those who are overweight or obese. Further large-scale clinical trials are needed to confirm these findings and the usefulness of TRE.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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