Cholesterol and Egg Intakes, and Risk of Hypertension in a Large Prospective Cohort of French Women
MacDonald CJ, Madika AL, Bonnet F, Fagherazzi G, Lajous M, Boutron-Ruault MC
Nutrients · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Agence Nationale de la Recherche
- Nonprofit
- Fédération Française de Cardiologie
- Nonprofit
- Ligue Contre le Cancer
- Nonprofit
- Mutuelle Générale de l'Education Nationale
- Nonprofit
- French League against Cancer
- University or hospital
- Gustave Roussy Institute
- Nonprofit
- Mutuelle Générale de l’Education Nationale
- Government
- French Research Agency
- Government
- European Community
- Grants
- Agence Nationale de la Recherche (ANR-10-COHO-0006)
Based on 9 listed funder(s).
Publication
- Published
- 2020-05-08 · Nutrients · vol. 12 · issue 5 · p. 1350
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 18 citations · more than 90% of similar papers · 2.4× the field average
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Obesity, Physical Activity, Diet · Consumer Attitudes and Food Labeling
- Keywords
- Medicine, Hazard ratio, Prospective cohort study, Proportional hazards model, Cohort, Cohort study, Cholesterol, Risk factor, Population, Internal medicine, Environmental health, Confidence interval
- MeSH
- humans, hypertension, cholesterol, dietary, risk, prospective studies, eating, eggs, adult, aged, middle aged, france, female, nutritional physiological phenomena, surveys and questionnaires, heart disease risk factors
6 authors
From FR, LU, MX, US
- Conor‐James MacDonaldUniversité Paris-Sud; Inserm; Université Paris-Saclay; Institut Gustave Roussy; Centre de recherche en Epidémiologie et Santé des Populations
- Anne‐Laure MadikaUniversité Paris-Sud; Inserm; Université de Lille; Université Paris-Saclay; Institut Gustave Roussy; Centre Hospitalier Universitaire de Lille; Centre de recherche en Epidémiologie et Santé des Populations
- Fabrice BonnetUniversité Paris-Sud; Inserm; Université Paris-Saclay; Institut Gustave Roussy; Centre de recherche en Epidémiologie et Santé des Populations; Centre Hospitalier Universitaire de Rennes; Université de Rennes
- Guy FagherazziUniversité Paris-Sud; Inserm; Université Paris-Saclay; Institut Gustave Roussy; Luxembourg Institute of Health; Centre de recherche en Epidémiologie et Santé des Populations
- Martín LajousInstituto Nacional de Salud Pública; Harvard Global Health Institute
- Marie‐Christine Boutron‐Ruault · correspondingUniversité Paris-Sud; Inserm; Université Paris-Saclay; Institut Gustave Roussy; Centre de recherche en Epidémiologie et Santé des Populations
Abstract
Purpose: The relationship between egg and cholesterol intakes, and cardiovascular disease is controversial. Meta-analyses indicate that egg consumption is associated with increased cardiovascular disease and mortality, but reduced incidence of hypertension, a major risk factor for cardiovascular disease. This study aims to investigate the associations between consumption of egg and cholesterol, and hypertension risk in a cohort of French women. Methods: We used data from the E3N cohort study, a French prospective population-based study initiated in 1990. From the women in the study, we included those who completed a detailed diet history questionnaire, and who did not have prevalent hypertension or cardiovascular disease at baseline, resulting in 46,424 women. Hypertension cases were self-reported. Egg and cholesterol intake was estimated from dietary history questionnaires. Cox proportional hazard models with time-updated exposures were used to calculate hazard ratios. Spline regression was used to determine any dose-respondent relationship. Results: During 885,321 person years, 13,161 cases of incident hypertension were identified. Higher cholesterol consumption was associated with an increased risk of hypertension : HRQ1-Q5 = 1.22 [1.14:1.30], with associations similar regarding egg consumption up to seven eggs per week: HR4-7 eggs = 1.14 [1.06:1.18]. Evidence for a non-linear relationship between hypertension and cholesterol intake was observed. Conclusion: Egg and cholesterol intakes were associated with a higher risk of hypertension in French women. These results merit further investigation in other populations.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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