25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2
D'Avolio A, Avataneo V, Manca A, Cusato J, De Nicolò A, Lucchini R, Keller F, Cantù M
Nutrients · 281 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2020-05-09 · Nutrients · vol. 12 · issue 5 · p. 1359
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 446 citations · more than 100% of similar papers · 54.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 11 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · COVID-19 Clinical Research Studies
- Keywords
- Medicine, Vitamin D and neurology, Internal medicine, Cohort, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Cohort study, Gastroenterology, Coronavirus disease 2019 (COVID-19), Population, Randomized controlled trial, vitamin D deficiency, Severity of illness, Respiratory system, Disease, Infectious disease (medical specialty)
- MeSH
- humans, pneumonia, viral, coronavirus infections, vitamin d, retrospective studies, polymerase chain reaction, age factors, dietary supplements, aged, aged, 80 and over, middle aged, switzerland, female, male, pandemics, betacoronavirus, covid-19, sars-cov-2
8 authors
From IT, CH
- Antonio D’Avolio · correspondingOspedale Amedeo di Savoia; University of Turin
- Valeria AvataneoOspedale Amedeo di Savoia; University of Turin
- Alessandra MancaOspedale Amedeo di Savoia; University of Turin
- Jessica CusatoOspedale Amedeo di Savoia; University of Turin
- Amedeo De NicolòOspedale Amedeo di Savoia; University of Turin
- Renzo LucchiniEnte Ospedaliero Cantonale
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. To date, it is unclear why some patients develop severe symptoms. Many authors have suggested the involvement of vitamin D in reducing the risk of infections; thus, we retrospectively investigated the 25-hydroxyvitamin D (25(OH)D) concentrations in plasma obtained from a cohort of patients from Switzerland. In this cohort, significantly lower 25(OH)D levels (p = 0.004) were found in PCR-positive for SARS-CoV-2 (median value 11.1 ng/mL) patients compared with negative patients (24.6 ng/mL); this was also confirmed by stratifying patients according to age >70 years. On the basis of this preliminary observation, vitamin D supplementation might be a useful measure to reduce the risk of infection. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations and to confirm our preliminary observation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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