The expression of opsins in the human skin and its implications for photobiomodulation: A Systematic Review
Suh S, Choi EH, Atanaskova Mesinkovska N
Photodermatology, photoimmunology & photomedicine · 52 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Eye Institute
- Government
- National Institute of General Medical Sciences
- Government
- Center for Scientific Review
- Government
- CSR NIH HHS
- Government
- NEI NIH HHS
- Government
- NIGMS NIH HHS
- Grants
- National Eye Institute (F30EY029136); Center for Scientific Review (F30EY029136); National Institute of General Medical Sciences (T32GM007250); National Eye Institute (T32EY024236); Center for Scientific Review (T32EY024236); Center for Scientific Review (T32GM007250); National Institutes of Health (T32‐GM007250); National Institutes of Health (F30EY029136); National Institutes of Health (T32EY024236)
Based on 7 listed funder(s).
Publication
- Published
- 2020-05-20 · Photodermatol Photoimmunol Photomed · vol. 36 · issue 5 · pp. 329–338
- Publisher
- Wiley
- Cited
- 76 citations · more than 88% of similar papers · 1.8× the field average
- References
- 65 works
- Access
- Open access (repository copy)
- Research areas
- Laser Applications in Dentistry and Medicine · Dermatologic Treatments and Research · Skin Protection and Aging
- Keywords
- Opsin, Biology, Zebrafish, Neuroscience, Dermatology, Evolutionary biology, Medicine, Genetics, Rhodopsin, Retinal
- MeSH
- skin, animals, humans, opsins
3 authors
From US
- Susie SuhUniversity of California, Irvine; Case Western Reserve University
- Elliot H. ChoiUniversity of California, Irvine; Case Western Reserve University
- Natasha Atanaskova Mesinkovska · correspondingUniversity of California, Irvine
Abstract
Background
Skin is the organ most extensively exposed to light of a broad range of wavelengths. Several studies have reported that skin expresses photoreceptive molecules called opsins. However, the identity and functional role of opsins in the human skin remain elusive. We aim to summarize current scientific evidence on the types of opsins expressed in the skin and their biological functions.
Methods
A primary literature search was conducted using PubMed to identify articles on dermal opsins found in nonhuman animals and humans.
Results
Twenty-two articles, representing, however, a non-exhaustive selection of the scientific papers published in this specific field, met the inclusion criteria. In nonhuman animals, opsins and opsin-like structures have been detected in the skin of fruit fly, zebrafish, frog, octopus, sea urchin, hogfish, and mouse, and they mediate skin color change, light avoidance, shadow reflex, and circadian photoentrainment. In humans, opsins are present in various skin cell types, including keratinocytes, melanocytes, dermal fibroblasts, and hair follicle cells. They have been shown to mediate wound healing, melanogenesis, hair growth, and skin photoaging.
Conclusion
Dermal opsins have been identified across many nonhuman animals and humans. Current evidence suggests that opsins have biological significance beyond light reception. In nonhuman animals, opsins are involved in behaviors that are critical for survival. In humans, opsins are involved in various functions of the skin although the underlying molecular mechanisms remain unclear. Future investigation on elucidating the mechanism of dermal opsins will be crucial to expand the therapeutic benefits of photobiomodulation for various skin disorders.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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