Funded in part by AFA Försäkring, Novo Nordisk Fonden
Consumption of red meat, genetic susceptibility, and risk of LADA and type 2 diabetes
Löfvenborg JE, Ahlqvist E, Alfredsson L, Andersson T, Groop L, Tuomi T, Wolk A, Carlsson S
European journal of nutrition · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Company
- AFA Försäkring
- University or hospital
- Karolinska Institutet
- Government
- Stockholms Läns Landsting
- Government
- Vetenskapsrådet
- Government
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Nonprofit
- Reumatikerförbundet
- Nonprofit
- Diabetesförbundet
- Company
- Novo Nordisk Fonden
- Government
- European Research Council Advanced Researcher grant
- Government
- European Research Council
- Government
- Swedish Research Council funding for clinical research
- Grants
- Novo Nordisk Fonden (NNF17OC0027396); Forskningsrådet om Hälsa, Arbetsliv och Välfärd (GA 2018-00337); Novo Nordisk Fonden (NNF19OC0057274); Vetenskapsrådet (GA 2018-03035)
Based on 11 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-05-22 · Eur J Nutr · vol. 60 · issue 2 · pp. 769–779
- Publisher
- Springer Science+Business Media
- Cited
- 20 citations · more than 89% of similar papers · 2.5× the field average
- References
- 39 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Diabetes and associated disorders · Nutritional Studies and Diet · Regulation of Appetite and Obesity
- Keywords
- Red meat, Type 2 diabetes, Medicine, Population, Diabetes mellitus, White meat, Processed meat, Food science, Biology, Environmental health, Endocrinology
- MeSH
- humans, diabetes mellitus, type 2, genetic predisposition to disease, diet, meat, adult, sweden, female, male, red meat, latent autoimmune diabetes in adults
8 authors
From SE, FI
- Josefin Edwall Löfvenborg · correspondingKarolinska Institutet
- Emma AhlqvistLund University
- Lars S. AlfredssonKarolinska Institutet
- Tomas L. G. AnderssonRegion Stockholm; Karolinska Institutet
- Leif GroopUniversity of Helsinki; Lund University; Institute for Molecular Medicine Finland
- Tiinamaija TuomiUniversity of Helsinki; Lund University; Helsinki University Hospital; Institute for Molecular Medicine Finland; Folkhälsans Forskningscentrum; Hospital District of Helsinki and Uusimaa
Abstract
Purpose
Red meat consumption is positively associated with type 1 (T1D) and type 2 (T2D) diabetes. We investigated if red meat consumption increases the risk of latent autoimmune diabetes in adults (LADA) and T2D, and potential interaction with family history of diabetes (FHD), HLA and TCF7L2 genotypes.
Methods
Analyses were based on Swedish case-control data comprising incident cases of LADA (n = 465) and T2D (n = 1528) with matched, population-based controls (n = 1789; n = 1553 in genetic analyses). Multivariable-adjusted ORs in relation to self-reported processed and unprocessed red meat intake were estimated by conditional logistic regression models. Attributable proportion (AP) due to interaction was used to assess departure from additivity of effects.
Results
Consumption of processed red meat was associated with increased risk of LADA (per one servings/day OR 1.27, 95% CI 1.07-1.52), whereas no association was observed for unprocessed red meat. For T2D, there was no association with red meat intake once BMI was taken into account. The combination of high (> 0.3 servings/day vs. less) processed red meat intake and high-risk HLA-DQB1 and -DRB1 genotypes yielded OR 8.05 (95% CI 4.86-13.34) for LADA, with indications of significant interaction (AP 0.53, 95% CI 0.32-0.73). Results were similar for the combination of FHD-T1D and processed red meat. No interaction between processed red meat intake and FHD-T2D or risk variants of TCF7L2 was seen in relation to LADA or T2D.
Conclusion
Consumption of processed but not unprocessed red meat may increase the risk of LADA, especially in individuals with FHD-T1D or high-risk HLA genotypes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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