Impact of passive heat acclimation on markers of kidney function during heat stress
Ravanelli N, Barry H, Schlader ZJ, Gagnon D
Experimental physiology · 27 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Government of Canada
- Government
- Canada Foundation for Innovation
- Government
- Natural Sciences and Engineering Research Council of Canada
- Grants
- Government of Canada (RGPIN-2017-04243); Canada Foundation for Innovation (35775)
Based on 3 listed funder(s).
Publication
- Published
- 2020-06-04 · Exp Physiol · vol. 106 · issue 1 · pp. 269–281
- Publisher
- Wiley
- Cited
- 32 citations · more than 90% of similar papers · 2.4× the field average
- References
- 77 works
- Access
- Paywalled
- Research areas
- Thermoregulation and physiological responses · Climate Change and Health Impacts · Thermal Regulation in Medicine
- Keywords
- Acclimatization, Renal function, Heat stress, Urine, Creatinine, Chemistry, Albuminuria, Internal medicine, Medicine, Endocrinology, Animal science, Biology, Ecology
- MeSH
- kidney, kidney glomerulus, humans, heat stress disorders, sodium, exercise, hyperthermia, induced, acclimatization, heat-shock response, adult, female, male, young adult
4 authors
From CA, US
- Nicholas RavanelliMontreal Heart Institute; Université de Montréal
- Hadiatou BarryMontreal Heart Institute; Université de Montréal
- Zachary J. SchladerIndiana University Bloomington
- Daniel Gagnon · correspondingMontreal Heart Institute; Université de Montréal
Abstract
New findings
What is the central question of this study? Does passive heat acclimation alter glomerular filtration rate and urine-concentrating ability in response to passive heat stress? What is the main finding and its importance? Glomerular filtration rate remained unchanged after passive heat stress, and heat acclimation did not alter this response. However, heat acclimation mitigated the reduction in urine-concentrating ability and reduced the incidence of albuminuria in young healthy adults after passive heat stress. Collectively, these results suggest that passive heat acclimation might improve structural integrity and reduce glomerular permeability during passive heat stress.
Abstract
Little is known about the effect of heat acclimation on kidney function during heat stress. The purpose of this study was to determine the impact of passive heat stress and subsequent passive heat acclimation on markers of kidney function. Twelve healthy adults (seven men and five women; 26 ± 5 years of age; 72.7 ± 8.6 kg; 172.4 ± 7.5 cm) underwent passive heat stress before and after a 7 day controlled hyperthermia heat acclimation protocol. The impact of passive heat exposure on urine and serum markers of kidney function was evaluated before and after heat acclimation. Glomerular filtration rate, determined from creatinine clearance, was unchanged with passive heat stress before (pre, 133 ± 41 ml min-1 ; post, 127 ± 51 ml min-1 ; P = 0.99) and after (pre, 129 ± 46 ml min-1 ; post, 130 ± 36 ml min-1 ; P = 0.99) heat acclimation. The urine-to-serum osmolality ratio was reduced after passive heating (P -1 ; post, 0.40 ± 1.01 ml min-1 ; P -1 ; post, 0.76 ± 1.2 ml min-1 ; P = 0.11) heat acclimation. Furthermore, passive heating increased the fractional excretion rate of potassium (P < 0.03) but not sodium (P = 0.13) or chloride (P = 0.20). Lastly, heat acclimation reduced the fractional incidence of albuminuria after passive heating (before, 58 ± 51%; after, 8 ± 29%; P = 0.03). Collectively, these results demonstrate that passive heat stress does not alter the glomerular filtration rate. However, heat acclimation might improve urine-concentrating ability and filtration within the glomerulus.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.