Higher ultra-processed food intake is associated with higher DNA damage in healthy adolescents
Edalati S, Edalati S, Bagherzadeh F, Asghari Jafarabadi M, Ebrahimi-Mamaghani M
The British journal of nutrition · 38 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- Tabriz University of Medical Sciences
- University or hospital
- University of Tabriz
Based on 2 listed funder(s).
Publication
- Published
- 2020-06-09 · Br J Nutr · vol. 125 · issue 5 · pp. 568–576
- Publisher
- Cambridge University Press
- Cited
- 47 citations · more than 95% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 109 works
- Access
- Free to read
- Research areas
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Obesity, Physical Activity, Diet
- Keywords
- Medicine, Confounding, Creatinine, Environmental health, Obesity, Food group, Urinary system, Mediterranean diet, Biomarker, Food science, Internal medicine, Biology
- MeSH
- humans, obesity, dna damage, body mass index, diet, sex factors, energy intake, food handling, adolescent, iran, female, male, young adult, biomarkers, edible grain, 8-hydroxy-2'-deoxyguanosine
4 authors
From IR
- Sareh EdalatiNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Farzaneh BagherzadehTabriz University of Medical Sciences
- Mohammad Asghari JafarabadiTabriz University of Medical Sciences
- Mehrangiz Ebrahimi‐Mameghani · correspondingTabriz University of Medical Sciences
Abstract
Ultra-processed food is one of the main contributors to energy supply and consumption in food systems worldwide, and evidence of their detrimental health outcomes in humans is emerging. This study aimed to assess ultra-processed food intake and its association with urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of DNA oxidative damage, in 139 healthy adolescents in Karaj City in Iran. Usual dietary intake was measured using a 168-item validated FFQ. The daily intake of ultra-processed food consumption was determined through the classification of NOVA, and general linear models were used to compare the urinary levels of 8-OHdG/creatinine (ng/mg creatinine) within tertiles of ultra-processed food intake. Adolescents in the higher tertile of ultra-processed food consumption had a significantly higher mean level of urinary 8-OHdG/creatinine in comparison with the lower tertiles in the crude model (Pfor trend: 0·003) and after adjustment for confounding variables, including total energy intake, sex, age, BMI for age Z-score, obesity and physical activity (Pfor trend: 0·004). This association was still significant after adjusting for dietary intake of whole grains, nuts, legumes, the ratio of MUFA:SFA (g/d) and Mediterranean dietary score (Pfor trend: 0·002). More studies are needed to explore the determinants of ultra-processed food supply, demand, consumption and health effects; such studies should be applied to develop evidence-informed policies and regulatory mechanisms to improve children's and adolescents' food environment policymaking and legislation with special attention to ultra-processed food.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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