Effect of Magnesium Supplementation on Circulating Biomarkers of Cardiovascular Disease
Alonso A, Chen LY, Rudser KD, Norby FL, Rooney MR, Lutsey PL
Nutrients · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Heart Association
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Nonprofit
- American Heart Association-American Stroke Association
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (T32HL007779); National Center for Advancing Translational Sciences ((UL1-TR002494)); National Heart, Lung, and Blood Institute (T32-HL-007024); National Heart, Lung, and Blood Institute (K24 HL148521); American Heart Association (16EIA26410001)
Based on 6 listed funder(s).
Publication
- Published
- 2020-06-06 · Nutrients · vol. 12 · issue 6 · p. 1697
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 8 citations · more than 67% of similar papers · 0.7× the field average
- References
- 32 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Iron Metabolism and Disorders
- Keywords
- Magnesium, Medicine, Placebo, Confidence interval, Internal medicine, Randomized controlled trial, Gastroenterology, Endocrinology, Chemistry, Pathology
- MeSH
- humans, cardiovascular diseases, magnesium, magnesium oxide, blood proteins, myoglobin, administration, oral, double-blind method, proteomics, dietary supplements, middle aged, female, tumor necrosis factor ligand superfamily member 13, biomarkers, tartrate-resistant acid phosphatase, interleukin-1 receptor-like 1 protein
6 authors
From US
- Álvaro Alonso · correspondingEmory University
- Lin Y. ChenUniversity of Minnesota
- Kyle D. RudserUniversity of Minnesota
- Faye L. NorbyUniversity of Minnesota
- Mary R. RooneyJohns Hopkins University
- Pamela L. LutseyUniversity of Minnesota
Abstract
(1) Background: Magnesium supplementation may be effective for the prevention of cardiometabolic diseases, but the mechanisms are unclear. Proteomic approaches can assist in identifying the underlying mechanisms. (2) Methods: We collected repeated blood samples from 52 individuals enrolled in a double-blind trial which randomized participants 1:1 to oral magnesium supplementation (400 mg magnesium/day in the form of magnesium oxide) or a matching placebo for 10 weeks. Plasma levels of 91 proteins were measured at baseline with follow-up samples using the Olink Cardiovascular Disease III proximity extension assay panel and were modeled as arbitrary units in a log2 scale. We evaluated the effect of oral magnesium supplementation for changes in protein levels and the baseline association between serum magnesium and protein levels. The Holm procedure was used to adjust for multiple comparisons. (3) Results: Participants were 73% women, 94% white, and had a mean age of 62. Changes in proteins did not significantly differ between the two intervention groups after correction for multiple comparisons. The most statistically significant effects were on myoglobin [difference -0.319 log2 units, 95% confidence interval (CI) (-0.550, -0.088), p = 0.008], tartrate-resistant acid phosphatase type 5 (-0.187, (-0.328, -0.045), p = 0.011), tumor necrosis factor ligand superfamily member 13B (-0.181, (-0.332, -0.031), p = 0.019), ST2 protein (-0.198, (-0.363, -0.032), p = 0.020), and interleukin-1 receptor type 1 (-0.144, (-0.273, -0.015), p = 0.029). Similarly, none of the associations of baseline serum magnesium with protein levels were significant after correction for multiple comparisons. (4) Conclusions: Although we did not identify statistically significant effects of oral magnesium supplementation in this relatively small study, this study demonstrates the value of proteomic approaches for the investigation of mechanisms underlying the beneficial effects of magnesium supplementation. Clinical Trials Registration: ClinicalTrials.gov NCT02837328.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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