Anti-Inflammatory Potential of n-3 Polyunsaturated Fatty Acids Enriched Hen Eggs Consumption in Improving Microvascular Endothelial Function of Healthy Individuals-Clinical Trial
Stupin A, Mihalj M, Kolobarić N, Šušnjara P, Kolar L, Mihaljević Z, Matić A, Stupin M, Jukić I, Kralik Z, Grčević M, Kralik G, Šerić V, Drenjančević I
International journal of molecular sciences · 30 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- European Structural and Investment Funds grant for the Croatian National Scientific Center of Excellence for Personalized Health Care, University of Josip Juraj Strossmayer Osijek
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-06-10 · Int J Mol Sci · vol. 21 · issue 11 · p. 4149
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 40 citations · more than 90% of similar papers · 2.5× the field average
- References
- 74 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Fatty Acid Research and Health · Cholesterol and Lipid Metabolism · Antioxidant Activity and Oxidative Stress
- Keywords
- Polyunsaturated fatty acid, Endothelium, Endocrinology, Internal medicine, Endothelial activation, Inflammation, Endothelial dysfunction, Microcirculation, Vasodilation, Sodium nitroprusside, Medicine, Chemistry, Nitric oxide, Biochemistry, Fatty acid
- MeSH
- endothelium, vascular, microcirculation, skin, animals, chickens, humans, fatty acids, omega-3, fatty acids, anti-inflammatory agents, non-steroidal, anti-inflammatory agents, cytokines, blood chemical analysis, body composition, vasodilation, eggs, food, fortified, adult, female, male, hemodynamics, young adult
14 authors
From HR
- Ana StupinUniversity of Osijek
- Martina MihaljUniversity of Osijek
- Nikolina KolobarićUniversity of Osijek
- Petar ŠušnjaraUniversity of Osijek
- Luka KolarPolytechnic Lavoslav Ružička Vukovar; University of Osijek
- Zrinka MihaljevićUniversity of Osijek
Abstract
The effects of consumption of n-3 polyunsaturated fatty acids (n-3 PUFAs) enriched hen eggs on endothelium-dependent and endothelium-independent vasodilation in microcirculation, and on endothelial activation and inflammation were determined in young healthy individuals. Control group (N = 21) ate three regular hen eggs/daily (249 mg n-3 PUFAs/day), and n-3 PUFAs group (N = 19) ate three n-3 PUFAs enriched hen eggs/daily (1053 g n-3 PUFAs/day) for 3 weeks. Skin microvascular blood flow in response to iontophoresis of acetylcholine (AChID; endothelium-dependent) and sodium nitroprusside (SNPID; endothelium-independent) was assessed by laser Doppler flowmetry. Blood pressure (BP), body composition, body fluid status, serum lipid and free fatty acids profile, and inflammatory and endothelial activation markers were measured before and after respective dietary protocol. Results: Serum n-3 PUFAs concentration significantly increased, AChID significantly improved, and SNPID remained unchanged in n-3 PUFAs group, while none was changed in Control group. Interferon-γ (pro-inflammatory) significantly decreased and interleukin-10 (anti-inflammatory) significantly increased in n-3 PUFAs. BP, fat free mass, and total body water significantly decreased, while fat mass, interleukin-17A (pro-inflammatory), interleukin-10 and vascular endothelial growth factor A significantly increased in the Control group. Other measured parameters remained unchanged in both groups. Favorable anti-inflammatory properties of n-3 PUFAs consumption potentially contribute to the improvement of microvascular endothelium-dependent vasodilation in healthy individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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