The Relation between Red Meat and Whole-Grain Intake and the Colonic Mucosal Barrier: A Cross-Sectional Study
Jawhara M, Sørensen SB, Heitmann BL, Halldórsson ÞI, Pedersen AK, Andersen V
Nutrients · 2 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Aarhus Universitet
- University or hospital
- Aarhus Universitetshospital
- Government
- European Commission
- University or hospital
- Syddansk Universitet
- Nonprofit
- Knud og Edith Eriksens Mindefond
- Government
- Horizon 2020 Framework Programme
- Government
- Horizon 2020
- Grants
- European Commission (HORIZON2020); Horizon 2020 Framework Programme (733100); European Commission (733100)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-06-12 · Nutrients · vol. 12 · issue 6 · p. 1765
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 4 citations · more than 56% of similar papers · 0.2× the field average
- References
- 70 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Food composition and properties · Probiotics and Fermented Foods
- Keywords
- Cross-sectional study, Red meat, Food science, Whole grains, Biology, Medicine, Pathology
- MeSH
- intestinal mucosa, colon, mucus, humans, colonoscopy, biopsy, in situ hybridization, fluorescence, diet, diet surveys, cross-sectional studies, adult, aged, aged, 80 and over, middle aged, denmark, female, male, mucin-2, microbiota, whole grains, red meat
6 authors
From DK, AU, IS
- Mohamad Jawhara · correspondingUniversity of Southern Denmark; Sygehus Sønderjylland
- Signe Bek SørensenUniversity of Southern Denmark
- Berit L. HeitmannUniversity of Copenhagen; The University of Sydney; Frederiksberg Hospital
- Thorhallur Ingi HalldorssonStatens Serum Institut; University of Iceland
- Andreas Kristian PedersenSygehus Sønderjylland
- Vibeke Charlotte AndersenUniversity of Southern Denmark
Abstract
The Colonic Mucosal Barrier (CMB) is the site of interaction between the human body and the colonic microbiota. The mucus is the outer part of the CMB and is considered as the front-line defense of the colon. It separates the host epithelial lining from the colonic content, and it has previously been linked to health and diseases. In this study, we assessed the relationship between red meat and whole-grain intake and (1) the thickness of the colonic mucus (2) the expression of the predominant mucin gene in the human colon (MUC2). Patients referred to colonoscopy at the University Hospital of Southern Denmark- Sonderjylland were enrolled between June 2017 and December 2018, and lifestyle data was collected in a cross-sectional study design. Colonic biopsies, blood, urine, and fecal samples were collected. The colonic mucus and bacteria were visualized by immunostaining and fluorescence in situ hybridization techniques. We found a thinner mucus was associated with high red meat intake. Similarly, the results suggested a thinner mucus was associated with high whole-grain intake, albeit to a lesser extent than red meat. This is the first study assessing the association between red meat and whole-grain intake and the colonic mucus in humans. This study is approved by the Danish Ethics Committee (S-20160124) and the Danish Data Protecting Agency (2008-58-035). A study protocol was registered at clinical trials.gov under NCT04235348.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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