Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α
Yu J, Liu H, He S, Li P, Ma C, Ma M, Liu Y, Lv L, Ping F, Zhang H, Li W, Sun Q, Xu L, Li Y
Mediators of inflammation · 8 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- CAMS Innovation Fund for Medical Sciences
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-05-22 · Mediators Inflamm · vol. 2020 · pp. 1–6
- Publisher
- Hindawi Publishing Corporation
- Cited
- 9 citations · more than 67% of similar papers · 0.7× the field average
- References
- 20 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Telomeres, Telomerase, and Senescence · Biomarkers in Disease Mechanisms · Nutrition and Health in Aging
- Keywords
- Medicine, Internal medicine, Odds ratio, Confidence interval, Endocrinology, Quartile, Magnesium, Chemistry
- MeSH
- leukocytes, telomere, humans, diabetes mellitus, type 2, inflammation, magnesium, blood glucose, tumor necrosis factor-alpha, anthropometry, diet, odds ratio, regression analysis, cross-sectional studies, oxidative stress, adult, aged, middle aged, female, male, real-time polymerase chain reaction, glycated hemoglobin
14 authors
From CN
- Jie YuChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Haibin LiuCapital Medical University
- Shuli HeChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Pingping LiChinese Academy of Medical Sciences & Peking Union Medical College
- Chunxiao Ma
- Minglei MaChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
Abstract
Objectives
In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL).
Designs
The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). However, few epidemiological studies have evaluated the effects of magnesium on LTL in the clinical setting. Participants. This cross-sectional analysis included 467 participants (34.8% men). Measurements. Serum blood lipid profile, HbA1c, oxidative stress, and proinflammatory mediator levels were measured. Detailed dietary data were obtained using a 24 h food recall. LTL was assessed using a real-time PCR assay. Regression models and simple regulatory models were used for data analysis.
Results
There was an inverse relationship between dietary magnesium and LTL (P α, with an interquarter difference of 3.79 pmol/mL (P for trend = 0.006). Multivariate regression analysis revealed that the odds ratios (ORs) for shorter LTL and higher serum TNFα increased with magnesium intake, and the ORs of the differences between extreme quartiles were 2.60 (95% confidence interval (CI): 1.31-5.36; P = 0.003) and 1.98 (95% CI: 1.09-3.59; P = 0.008). There was a direct negative effect of dietary magnesium intake on LTL (B = -0.002; P = 0.001), which appeared to be indirectly influenced by TNFα (-0.002 to -0.0005).
Conclusions
Dietary magnesium intake may be a critical component of the cellular aging process, and its effect could be partly mediated by TNFα.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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