The Effect of Caffeine on the Risk and Progression of Parkinson's Disease: A Meta-Analysis
Hong CT, Chan L, Bai CH
Nutrients · 76 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2020-06-22 · Nutrients · vol. 12 · issue 6 · p. 1860
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 114 citations · more than 95% of similar papers · 3.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 58 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Coffee research and impacts · Parkinson's Disease Mechanisms and Treatments · Adenosine and Purinergic Signaling
- Keywords
- Caffeine, Medicine, Hazard ratio, Cohort, Internal medicine, Parkinson's disease, Disease, Cohort study, Lower risk, Dyskinesia, Confidence interval
- MeSH
- humans, parkinson disease, disease progression, levodopa, caffeine, proportional hazards models, cohort studies, coffee
3 authors
From TW
- Chien‐Tai HongTaipei Medical University-Shuang Ho Hospital; Taipei Medical University
- Lung Chan · correspondingTaipei Medical University-Shuang Ho Hospital; Taipei Medical University
- Chyi‐Huey Bai · correspondingTaipei Medical University Hospital; Taipei Medical University
Abstract
Coffee and caffeine are speculated to be associated with the reduced risk of Parkinson's disease (PD). The present study aimed to investigate the disease-modifying potential of caffeine on PD, either for healthy people or patients, through a meta-analysis. The electronic databases were searched using terms related to PD and coffee and caffeinated food products. Articles were included only upon fulfillment of clear diagnostic criteria for PD and details regarding their caffeine content. Reference lists of relevant articles were reviewed to identify eligible studies not shortlisted using these terms. In total, the present study enrolled 13 studies, nine were categorized into a healthy cohort and the rest into a PD cohort. The individuals in the healthy cohort with regular caffeine consumption had a significantly lower risk of PD during follow-up evaluation (hazard ratio (HR) = 0.797, 95% CI = 0.748-0.849, p p = 0.03). In conclusion, caffeine modified disease risk and progression in PD, among both healthy individuals or those with PD. Potential biological benefits, such as those obtained from adenosine 2A receptor antagonism, may require further investigation for designing new drugs.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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