Creatine supplementation improves performance, but is it safe? Double-blind placebo-controlled study
Almeida D, Colombini A, Machado M
The Journal of sports medicine and physical fitness · 14 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-06-01 · J Sports Med Phys Fitness · vol. 60 · issue 7 · pp. 1034–1039
- Publisher
- Edizioni Minerva Medica
- Cited
- 31 citations · more than 77% of similar papers · 1.4× the field average
- References
- 33 works
- Access
- Paywalled
- Research areas
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Thermoregulation and physiological responses
- Keywords
- Creatine, Medicine, Placebo, Creatine Monohydrate, Urine, Renal function, Internal medicine, Placebo-controlled study, Creatinine, Physiology, Double blind, Pathology
- MeSH
- muscle, skeletal, liver, kidney, humans, weight gain, creatine, lipids, hematologic tests, leukocyte count, double-blind method, dietary supplements, adult, male, athletic performance, resistance training, young adult, performance-enhancing substances, biomarkers
3 authors
From IT, BR
- Douglas Lopes Almeida
- Alessandra Colombini · correspondingIRCCS Ospedale Galeazzi - Sant'Ambrogio; Istituti di Ricovero e Cura a Carattere Scientifico
- Marco MachadoFundação Universitária de Itaperuna
Abstract
Background
Creatine represents a natural supplement and ergogenic aid for sport performance, but there are several concerns regarding its safety for health. The present double-blind placebo-controlled study evaluated the effect of creatine monohydrate supplementation on a panel of blood and urine health indicators in resistance training practitioners.
Methods
Eighteen males performing resistance training three times per week were supplemented with 0.3 g/kg per day creatine monohydrate for 7 days and compared with matched controls supplemented with dextrosol. Blood and urine samples were collected pre- and 30 days post-supplementation to evaluate 41 biochemical parameters and renal function.
Results
Creatine monohydrate supplementation did not cause adverse events and, as expected, promoted an increase of the performance and body weight. No modification of red blood cells parameters, white blood cells profile, blood lipid profile, metabolic and urine markers, hepatic and renal function were observed in the supplemented group.
Conclusions
Despite the expected weight increase, the creatine monohydrate supplementation is safe for health and no detrimental effects on different organs and physiological systems were observed in our cohort of volunteers.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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