A Prospective Analysis of Intake of Red and Processed Meat in Relation to Pancreatic Cancer among African American Women
Petrick JL, Castro-Webb N, Gerlovin H, Bethea TN, Li S, Ruiz-Narváez EA, Rosenberg L, Palmer JR
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 17 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Government
- NIH
- Nonprofit
- Karin Grunebaum Cancer Research Foundation
- Grants
- National Cancer Institute (K01-CA212056); National Cancer Institute (U01 CA187508); National Cancer Institute (U01-CA164974); National Cancer Institute (R01- CA058420); National Institutes of Health (U01 CA164974); National Institutes of Health (U01 CA187508)
Based on 5 listed funder(s).
Publication
- Published
- 2020-07-01 · Cancer Epidemiol Biomarkers Prev · vol. 29 · issue 9 · pp. 1775–1783
- Publisher
- American Association for Cancer Research
- Cited
- 26 citations · more than 84% of similar papers · 1.4× the field average
- References
- 71 works
- Access
- Open access (repository copy)
- Research areas
- Pancreatic and Hepatic Oncology Research · Nutritional Studies and Diet · Pancreatitis Pathology and Treatment
- Keywords
- Red meat, Pancreatic cancer, Medicine, Processed meat, Saturated fat, Incidence (geometry), Prospective cohort study, Cancer, Confidence interval, Food group, Proportional hazards model, Internal medicine, Food science, Environmental health, Biology, Cholesterol, Pathology
- MeSH
- humans, pancreatic neoplasms, incidence, prospective studies, adult, aged, middle aged, female, young adult, red meat, black or african american
8 authors
From US
- Jessica L. PetrickBoston University
- Nelsy Castro‐WebbBoston University
- Hanna GerlovinBoston University
- Traci N. BetheaGeorgetown University
- Shanshan LiBoston University
- Edward Ruiz-NarváezUniversity of Michigan
Abstract
Background
African Americans have the highest incidence of pancreatic cancer of any racial/ethnic group in the United States. There is evidence that consumption of red or processed meat and foods containing saturated fats may increase the risk of pancreatic cancer, but there is limited evidence in African Americans.
Methods
Utilizing the Black Women's Health Study (1995-2018), we prospectively investigated the associations of red and processed meat and saturated fats with incidence of pancreatic adenocarcinoma (n = 168). A food frequency questionnaire was completed by 52,706 participants in 1995 and 2001. Multivariable-adjusted HRs and 95% confidence intervals (CI) were estimated using Cox proportional hazards regression. We observed interactions with age (P interaction = 0.01). Thus, results were stratified at age 50 (<50, ≥50).
Results
Based on 148 cases among women aged ≥50 years, total red meat intake was associated with a 65% increased pancreatic cancer risk (HRQ4 vs. Q1 = 1.65; 95% CI, 0.98-2.78; P trend = 0.05), primarily due to unprocessed red meat. There was also a nonsignificant association between total saturated fat and pancreatic cancer (HRQ4 vs. Q1 = 1.85; 95% CI, 0.92-3.72; P trend = 0.08). Red meat and saturated fat intakes were not associated with pancreatic cancer risk in younger women, and there was no association with processed meat in either age group.
Conclusions
Red meat-specifically, unprocessed red meat-and saturated fat intakes were associated with an increased risk of pancreatic cancer in African-American women aged 50 and older, but not among younger women.
Impact
The accumulating evidence-including now in African-American women-suggests that diet, a modifiable factor, plays a role in the etiology of pancreatic cancer, suggesting opportunities for prevention.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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