Association between Egg Consumption and Cholesterol Concentration: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Li MY, Chen JH, Chen C, Kang YN
Nutrients · 30 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Taipei Medical University
- University or hospital
- Wan Fang Hospital
- Grants
- Taipei Medical University (108-wf-eva-01)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-07-04 · Nutrients · vol. 12 · issue 7 · p. 1995
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 32 citations · more than 63% of similar papers · 0.7× the field average
- References
- 63 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease
- Keywords
- Confidence interval, Meta-analysis, Randomized controlled trial, Cholesterol, Medicine, Internal medicine, Subgroup analysis, Lipoprotein, High-density lipoprotein, Endocrinology, Gastroenterology, Animal science, Biology
- MeSH
- humans, diet, diet surveys, eating, eggs, adolescent, adult, aged, middle aged, female, male, cholesterol, ldl, cholesterol, hdl, randomized controlled trials as topic, young adult
4 authors
From TW
- Man-Yun LiTaipei Medical University
- Jinhua ChenWan Fang Hospital; Taipei Medical University
- Chiehfeng Chen · correspondingWan Fang Hospital; Taipei Medical University
- Yi‐No Kang · correspondingNational Taiwan University; Wan Fang Hospital; Taipei Medical University
Abstract
The association of egg consumption and serum cholesterol concentrations in healthy people has been discussed for a long time. In this study, we aimed to explore association of egg consumption with on low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) concentrations and the LDL-c/HDL-c ratio through meta-analysis. This systematic review only included randomized controlled trials (RCTs) investigating egg consumption in healthy populations without combination therapy. We extracted mean and standard deviation for LDL-c/HDL-c ratio, LDL-c/HDL-c. The extracted data were pooled in a random-effects model and were presented as mean difference (MD) with 95% confidence interval (CI). Moreover, subgroup analyses were conducted for understanding effects of more egg consumption (MEC) on different intervention periods, egg-consumption levels, classification of responders. Overall, 17 RCTs met the eligibility criteria and pooled results showed MEC group had a higher LDL-c/HDL-c ratio than the control group (MD = 0.14, p = 0.001, I2 = 25%). The MEC group also had higher LDL-c than the control group (MD = 8.14, p 2 = 18%). Moreover, for the subset of intervention over two months, the MEC group seemed to have a larger effect size than the subset of intervention within two months. This synthesis, the largest meta-analysis on this topic, shows the impact of egg consumption on lipid profiles among healthy subjects. Notably, longer time with MEC may lead to higher LDL-c/HDL-c ratio and LDL-c. However, RCTs with long tern follow-up are needed to guarantee the association between egg consumption and human health.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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