The Effects of Cold Water Immersion and Active Recovery on Molecular Factors That Regulate Growth and Remodeling of Skeletal Muscle After Resistance Exercise
Peake JM, Markworth JF, Cumming KT, Aas SN, Roberts LA, Raastad T, Cameron-Smith D, Figueiredo VC
Frontiers in physiology · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American College of Sports Medicine
- University or hospital
- Queensland University of Technology
- University or hospital
- University of Queensland
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-06-30 · Front Physiol · vol. 11 · p. 737
- Publisher
- Frontiers Media
- Cited
- 13 citations · more than 65% of similar papers · 0.7× the field average
- References
- 54 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle Physiology and Disorders · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Keywords
- Muscle hypertrophy, Endocrinology, Internal medicine, Skeletal muscle, Myostatin, Tenascin C, Medicine, Myosin, Biology, Chemistry, Cell biology, Immunohistochemistry
8 authors
From AU, NZ, US, NO, SG
- Jonathan M. Peake · correspondingQueensland University of Technology; Queensland Academy of Sport
- James F. MarkworthUniversity of Auckland; University of Michigan
- Kristoffer Toldnes CummingNorwegian School of Sport Sciences
- Sigve N. AasNorwegian School of Sport Sciences
- Llion Arwyn RobertsGriffith University; The University of Queensland; Queensland Academy of Sport
- Truls RaastadNorwegian School of Sport Sciences
Abstract
Regular postexercise cooling attenuates muscle hypertrophy, yet its effects on the key molecular factors that regulate muscle growth and remodeling are not well characterized. In the present study, nine men completed two sessions of single-leg resistance exercise on separate days. On 1 day, they sat in cold water (10°C) up to their waist for 10 min after exercise. On the other day, they exercised at a low intensity for 10 min after exercise. Muscle biopsies were collected from the exercised leg before, 2, 24, and 48 h after exercise in both trials. These muscle samples were analyzed to evaluate changes in genes and proteins involved in muscle growth and remodeling. Muscle-specific RING finger 1 mRNA increased at 2 h after both trials (P P P P P < 0.05). Myostatin mRNA and ubiquitin protein expression did not change after either trial. These responses were not significantly different between the trials. The present findings suggest that regular cold water immersion attenuates muscle hypertrophy independently of changes in factors that regulate myogenesis, proteolysis and extracellular matrix remodeling in muscle after exercise.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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