Effects of Ramadan intermittent fasting on inflammatory and biochemical biomarkers in males with obesity
Zouhal H, Bagheri R, Ashtary-Larky D, Wong A, Triki R, Hackney AC, Laher I, Abderrahman AB
Physiology & behavior · 50 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-07-23 · Physiol Behav · vol. 225 · p. 113090
- Publisher
- Elsevier BV
- Cited
- 64 citations · more than 95% of similar papers · 3.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 71 works
- Access
- Open access (hybrid journal) · OTHER-OA
- Research areas
- Dietary Effects on Health · Genetics, Aging, and Longevity in Model Organisms · Immune responses and vaccinations
- Keywords
- Intermittent fasting, Obesity, Medicine, Endocrinology, Internal medicine, Inflammation, Physiology
- MeSH
- humans, obesity, c-reactive protein, fasting, islam, male, biomarkers
8 authors
From FR, IR, US, TN, CA
- Hassane Zouhal · correspondingUniversité Rennes 2; Laboratoire Mouvement Sport Santé; Université de Rennes
- Reza BagheriIsfahan University of Technology; University of Isfahan
- Damoon Ashtary‐LarkyAhvaz Jundishapur University of Medical Sciences
- Alexei WongMarymount University; Marymount Manhattan College
- Raoua TrikiInstitute of Semitic Studies; Manouba University
- Anthony C. HackneyUniversity of North Carolina at Chapel Hill
Abstract
Background
To determine the effects of Ramadan intermittent fasting (RIF) on inflammatory (C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)) and biochemical markers of liver-renal function (aspartate aminotransferase (AST), alanine amino transferase (ALT), bilirubin, lactate dehydrogenase (LDH), urea and creatinine) in males with obesity.
Materials and methods
Twenty-eight males with obesity were randomly allocated to an experimental group (EG, n = 14) or a control group (CG, n = 14). The EG group completed their fasting rituals for the entire month of Ramadan (30 days) whereas the CG group continued with their normal daily habits. Blood samples were collected 24 h before the start of Ramadan (T0), on the 15th day of Ramadan (T1), the day after the end of Ramadan (T2), and 21 days after the end of Ramadan (T3). Resting plasma volume variation between pre and post-RIF (ΔPV) was calculated.
Results
Decreases were noted for interleukin-6 (p = 0.02, d = 1.4) and tumor necrosis factor-alpha (p = 0.01, d = 0.7), with no changes for C-reactive protein (p = 0.3; d = 0.1) in the EG compared to CG group. There were no changes (P > 0.05) in ΔPV recorded after RIF for either EG (-0.035 ± 0.02%) and CG (0.055 ± 0.06%).
Conclusion
This study demonstrates that RIF improves systemic inflammation biomarkers in males with obesity. Moreover, RIF did not negatively affect biomarkers of liver and renal function.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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