Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption
Pereira da Silva A, Costa MDC, Aguiar L, Matos A, Gil Â, Gorjão-Clara J, Polónia J, Bicho M
Oxidative medicine and cellular longevity · 2 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Universidade de Lisboa
- Government
- Fundação para a Ciência e a Tecnologia
- Grants
- Fundação para a Ciência e a Tecnologia (UIDB/04295/2020); Universidade de Lisboa (UIDB/04295/2020)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-07-03 · Oxid Med Cell Longev · vol. 2020 · pp. 1–14
- Publisher
- Hindawi Publishing Corporation
- Cited
- 6 citations · more than 55% of similar papers · 0.5× the field average
- References
- 86 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Genetics, Aging, and Longevity in Model Organisms · Renin-Angiotensin System Studies · Mitochondrial Function and Pathology
- Keywords
- Longevity, Consumption (sociology), Red meat, Biology, Medicine, Food science, Genetics
- MeSH
- humans, cardiovascular diseases, case-control studies, life style, longevity, female, male, red meat, heart disease risk factors
8 authors
From PT
- Alda Pereira da Silva · correspondingUniversity of Lisbon; Instituto de Investigação Científica Tropical; Universidade Lusófona
- Maria do Céu CostaEscola Superior de Saúde Ribeiro Sanches; Universidade Lusófona
- Laura Gonçalves Rodrigues AguiarUniversity of Lisbon; Instituto de Investigação Científica Tropical
- Andreia MatosUniversity of Lisbon; Instituto de Investigação Científica Tropical
- Ângela GilUniversity of Lisbon
- João Gorjão ClaraUniversity of Lisbon
Abstract
Background
Cardiovascular risk (CVR) underlies aging process and longevity. Previous work points to genetic and environmental factors associated with this risk.
Objectives
The aim of this research is to look for any CVR gene-gene and gene-multifactorial/lifestyle interactions that may impact health and disease and underlie exceptional longevity.
Methods
A case-control study involving 521 both gender individuals, 253 centenarians (100.26 ± 1.98 years), and 268 controls (67.51 ± 3.25 years), low (LCR, n = 107) and high (HCR, n = 161) CVR. Hypertension, diabetes, obesity (BMI, kg·m-2), and impaired kidney function were defined according to standard criteria. CVR was calculated using Q risk®. DNA was genotyping (ACE-rs4646994, AGT-rs4762, AGR1-rs5182, GRK4-rs2960306, GRK4-rs1024323, NOS3-rs1799983, and SLC12A3-rs13306673) through iPlex-MassARRAY®, read by MALDI-TOF mass spectrometry, and analyzed by EARTDECODE®.
Results
Antilongevity factors consisted (OR 95% CI, p ACE II (OR: 3.96 (1.83-8.56), p NOS3 TT (OR: 3.11 (1.70-5.70), p NOS3 genotypes and the severity of arterial hypertension. An epistatic interaction between functional genetic variants of GRK4 and angiotensinogen was also observed.
Conclusions
Cardiovascular risk-related genetic and multifactorial or predominantly lifestyle aspects and its interactions might influence the aging process and contribute to exceptional longevity in Portuguese centenarians. Besides lifestyle, the activity of nitrite oxide synthase may be one of the main physiologic regulators of cardiovascular protection in the path of longevity.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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