High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients
de Queiroz NNM, de Melo FTC, de Souza Resende F, Janaú LC, de Souza Neto NJK, de Lemos MN, de Oliveira MCNI, de Alcântara AL, de Moraes LV, da Mota Queiroz A, de Souza ÍJA, Said NM, Dos Santos MC, de Souza D'Albuquerque Silva L, Motta ARB, de Sá Oliveira Dos Reis M, Lobato IJC, de Figueiredo PBB, de Souza ACCB, Freire Piani PP, Felício KM, Abrahão Neto JF, Felício JS
Current diabetes reviews · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-07-30 · Curr Diabetes Rev · vol. 17 · issue 3 · pp. 378–386
- Publisher
- Bentham Science Publishers
- Cited
- 6 citations · more than 64% of similar papers · 0.5× the field average
- References
- 58 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Vitamin D Research Studies · HIV-related health complications and treatments · Vitamin K Research Studies
- Keywords
- Medicine, Blood pressure, Ambulatory blood pressure, Morning, Glycated hemoglobin, Internal medicine, Vitamin D and neurology, Diabetes mellitus, Endocrinology, Evening, Bedtime, Cholecalciferol, Type 2 diabetes
- MeSH
- humans, vitamin d deficiency, cholecalciferol, blood pressure monitoring, ambulatory, blood pressure, dietary supplements
23 authors
From BR
- Natércia Neves Marques de QueirozUniversidade Federal do Pará
- Franciane Trindade Cunha de MeloUniversidade Federal do Pará
- Fabrício de Souza ResendeUniversidade Federal do Pará
- Luísa Corrêa JanaúUniversidade do Estado do Pará
- Norberto Jorge Kzan de Souza NetoUniversidade Federal do Pará
- Manuela Nascimento de LemosUniversidade Federal do Pará
Abstract
Background
Vitamin D (VD) deficiency has been related to several endocrine metabolic and cardiovascular diseases. The effect of VD supplementation on blood pressure (BP) in patients with diabetes is controversial.
Objective
The aim of this study was to evaluate high-dose vitamin D supplementation effects on blood pressure of normotensive patients with diabetes mellitus 1 (DM1) patients by 24-hour ambulatory blood pressure monitoring (ABPM).
Methods
We performed a clinical trial including 35 DM1 normotensive patients, who received doses of 4,000 or 10,000 IU/day of cholecalciferol for 12 weeks according to previous VD levels. They underwent 24-hour ABPM, along with glycated hemoglobin, creatine, lipids profile and PCRus dosage before and after VD supplementation.
Results
We found an expressive reduction of systolic and diastolic morning blood pressures (117±14 vs 112±14, p<0,05; 74±9 vs 70±10 mmHg, p<0,05, respectively) with no changes in other pressoric markers. Besides, we noticed a relationship between levels of VD after supplementation and diastolic morning blood pressure (r= -0,4; p<0.05).
Conclusion
Our study suggests an association between supplementation of high doses of vitamin D and the reduction of morning blood pressure in normotensive DM1 patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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