Association between dietary contribution of ultra-processed foods and urinary concentrations of phthalates and bisphenol in a nationally representative sample of the US population aged 6 years and older
Martínez Steele E, Khandpur N, da Costa Louzada ML, Monteiro CA
PloS one · 93 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- No health outcome
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Grants
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2018/17972‐9); Fundação de Amparo à Pesquisa do Estado de São Paulo (2015/); Fundação de Amparo à Pesquisa do Estado de São Paulo (15/14900-9)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-07-31 · PLoS One · vol. 15 · issue 7 · p. e0236738
- Publisher
- Public Library of Science
- Cited
- 124 citations · more than 99% of similar papers · 11.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 58 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Effects and risks of endocrine disrupting chemicals · Nutritional Studies and Diet
- Keywords
- Phthalate, National Health and Nutrition Examination Survey, Medicine, Environmental health, Benzhydryl compounds, Obesity, Population, Cross-sectional study, Bisphenol A, Food science, Endocrinology, Chemistry, Pathology
- MeSH
- humans, phthalic acids, benzhydryl compounds, phenols, sulfones, estrogens, non-steroidal, food additives, diet, nutrition surveys, cross-sectional studies, public health, food handling, adolescent, adult, middle aged, child, female, male, young adult, fast foods, bisphenol a compounds, bisphenol s compounds, bisphenol f compounds
4 authors
From BR, US
- Eurídice Martínez Steele · correspondingUniversidade de São Paulo
- Neha Khandpur · correspondingHarvard University; Universidade de São Paulo
- Maria Laura da Costa Louzada · correspondingUniversidade de São Paulo
- Carlos Augusto Monteiro · correspondingUniversidade de São Paulo
Abstract
Ultra-processed food consumption has been associated with several health outcomes such as obesity, hypertension, cardiovascular disease and cancer. The deleterious nutrient profile of these products, and the presence of food additives, neoformed contaminants and contact materials such as phthalates and bisphenol may be some of the potential pathways through which ultra-processed food influences disease outcomes. The aim of this study was to examine the association between dietary contribution of ultra-processed foods and urinary biomarker concentrations of parent compounds or their metabolites including Di(2-ethylhexyl) phthalate (ΣDEHP), Di-isononyl phthalate (ΣDiNP), Monocarboxynonyl phthalate (mCNP), Mono (3-carboxypropyl) phthalate (mCPP), Monobenzyl phthalate (mBzP), Bisphenol A (BPA), Bisphenol F (BPF) and Bisphenol S (BPS), in the US. Participants from the cross-sectional 2009-2016 National Health and Nutrition Examination Survey, aged 6+ years, with urinary measures and with one 24-hour dietary recall were included in the study. Ultra-processed foods were identified based on the NOVA classification system, a four-group food classification based on the extent and purpose of industrial food processing. Linear regression was used to compare average urinary creatinine-standardized concentrations across quintiles of energy contribution of ultra-processed foods. Models incorporated survey sample weights and were adjusted for different sociodemographic and life-style variables. Adjusted geometric means of ΣDiNP, mCNP, mCPP, mBzP and BPF increased monotonically from the lowest to the highest quintile of ultra-processed food consumption. As both phthalates/bisphenol and ultra-processed foods have been previously associated with insulin resistance, diabetes, general/abdominal obesity and hypertension, our results suggest the possibility of contact materials in ultra-processed foods as one link between ultra-processed food and these health outcomes. Future studies could confirm findings and further explore these mechanisms of action.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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