25-Hydroxyvitamin D status, vitamin D intake, and skin cancer risk: a systematic review and dose-response meta-analysis of prospective studies
Mahamat-Saleh Y, Aune D, Schlesinger S
Scientific reports · 45 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Imperial College London
- Government
- Institut National de la Santé et de la Recherche Médicale
- Government
- Institut National Du Cancer
- Nonprofit
- World Cancer Research Fund
- Government
- National Cancer Institute
- Government
- the Paris Ile-de-France region
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-08-04 · Sci Rep · vol. 10 · issue 1 · p. 13151
- Publisher
- Nature Portfolio
- Cited
- 75 citations · more than 95% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 120 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Psoriasis: Treatment and Pathogenesis · Skin Protection and Aging
- Keywords
- Vitamin D and neurology, Medicine, Skin cancer, Meta-analysis, Prospective cohort study, Internal medicine, Relative risk, Confidence interval, Cancer, vitamin D deficiency, Melanoma, Oncology, Basal cell carcinoma, Basal (medicine), Vitamin, Physiology, Gastroenterology, Basal cell, Cancer research
- MeSH
- humans, skin neoplasms, vitamin d, risk factors, prospective studies, dose-response relationship, drug, basal cell carcinoma
3 authors
From FR, NO, GB, DE
- Yahya Mahamat‐Saleh · correspondingUniversité Paris-Sud; Inserm; Université de Versailles Saint-Quentin-en-Yvelines; Université Paris-Saclay; Institut Gustave Roussy; Centre de recherche en Epidémiologie et Santé des Populations
- Dagfinn AuneOslo University Hospital; Oslo Nye Høyskole; Imperial College London
- Sabrina SchlesingerDeutsches Diabetes-Zentrum e.V.; Heinrich Heine University Düsseldorf
Abstract
Sun exposure is a major environmental risk factor for skin cancers and is also an important source of vitamin D. However, while experimental evidence suggests that vitamin D may have a protective effect on skin cancer risk, epidemiologic studies investigating the influence of 25-hydroxyvitamin D (25(OH)D) level and/or vitamin D intake on skin cancer risk are conflicting. A systematic review and dose-response meta-analyses of prospective studies was conducted to clarify these associations. Relevant studies were identified by searching the PubMed database up to 30th August 2019. Random effects dose-response meta-analyses were used to estimate summary relative risks (SRRs) and 95% confidence intervals (CIs). Overall, thirteen prospective studies were included. Circulating level of 25(OH)D was associated with higher risks of melanoma (SRR (95% CI) per 30 nmol = 1.42 (1.17-1.72)) and keratinocyte cancer (KC) (SRR (95% CI) per 30 nmol/L = 1.30 (1.13-1.49)). The SRR (95% CI) per 30 nmol/L increase in 25(OH) D level was 1.41 (1.19-1.67), and 1.57 (0.64-3.86), for basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs), respectively. However, while we found that vitamin D intake (from diet, supplemental and total) was not associated with risks of melanoma and SCC, vitamin D intake was associated with slightly increased BCC risk, albeit with no heterogeneity across skin cancer type. This meta-analysis suggests positive associations between circulating 25(OH)D level and risk of melanoma and KC, however, this finding is most likely confounded by sun exposure. We found no associations between vitamin D intake skin cancers, except positive associations with BCC risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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