Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population
Yang N, He L, Li Y, Xu L, Ping F, Li W, Zhang H
Diabetes, metabolic syndrome and obesity : targets and therapy · 12 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Chinese Academy of Medical Sciences
- University or hospital
- Peking Union Medical College
- Government
- National Institutes of Health
- University or hospital
- University of North Carolina at Chapel Hill
- University or hospital
- China-Japan Friendship Hospital
- Government
- Fogarty International Center
- University or hospital
- Carolina Population Center, University of North Carolina at Chapel Hill
- Grants
- Chinese Academy of Medical Sciences (2019XK320029); Chinese Academy of Medical Sciences (CIFMS2016-I2M-4-001); National Natural Science Foundation of China (91846106)
Based on 8 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-07-01 · Diabetes Metab Syndr Obes · vol. Volume 13 · pp. 2541–2550
- Publisher
- Dove Medical Press
- Cited
- 19 citations · more than 74% of similar papers · 1.0× the field average
- References
- 39 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Aluminum toxicity and tolerance in plants and animals
- Keywords
- Insulin resistance, Quartile, Medicine, Metabolic syndrome, Magnesium, Odds ratio, Internal medicine, Endocrinology, Population, Mediation, Insulin, Diabetes mellitus, Confidence interval, Chemistry, Environmental health
7 authors
From CN
- Na Young Yang · correspondingChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Liyun He · correspondingChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yuxiu Li · correspondingChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Lingling Xu · correspondingChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Fan Ping · correspondingChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Wei Li · correspondingChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
Abstract
Purpose
High dietary magnesium intake may reduce insulin resistance (IR) and metabolic syndrome (MetS). The aim of the cross-sectional analysis was to evaluate the association between dietary magnesium intake, IR, and MetS using data from China Health and Nutrition Survey.
Methods
Dietary magnesium intake was defined as daily dietary magnesium intake divided by body weight. Logistic regression analysis was used to calculate the odds ratio (OR) for IR and the prevalence of MetS across the quartile categories of dietary magnesium intake. In addition, we used the macro PROCESS to perform the mediation analyses.
Results
A total of 8120 participants were included in the final analysis. We found a significant negative association between dietary magnesium intake and IR, the multivariable-adjusted OR for HOMA-IR comparing the highest to the lowest quartile of dietary magnesium intake was 0.435 (95% confidence intervals [CI] 0.376 to 0.502). The prevalence of the MetS was 38.6%, 28.9%, 22.5%, and 16.5% for increasing quartiles of dietary magnesium intake (p <0.001). The mediation model analysis displayed that insulin resistance mediated the effect of dietary magnesium on MetS. The direct effect and indirect effect of dietary magnesium on MetS were found significant, and the calculated percentage of mediation by insulin resistance was 19.6%.
Conclusion
Our study demonstrated a significant and independent negative relationship among weight-adjusted dietary magnesium intake, HOMA-IR, and MetS in a large Chinese population. IR partly mediated the relationship between dietary magnesium intake and MetS.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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