The haplotype of SLC2A9_rs3733591, PKD2_rs2725220 and ABCG2_rs2231142 increases the hyperuricaemia risk and alcohol, chicken and processed meat intakes and smoking interact with its risk
Yang HJ, Liu M, Kim MJ, Park S
International journal of food sciences and nutrition · 9 citations
Review labels
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How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-08-17 · Int J Food Sci Nutr · vol. 72 · issue 3 · pp. 391–401
- Publisher
- Taylor & Francis
- Cited
- 15 citations · more than 79% of similar papers · 1.3× the field average
- References
- 26 works
- Access
- Paywalled
- Research areas
- Gout, Hyperuricemia, Uric Acid · Diet, Metabolism, and Disease · Alcohol Consumption and Health Effects
- Keywords
- Haplotype, Minor allele frequency, Single-nucleotide polymorphism, Allele, Gout, Medicine, Genome-wide association study, Internal medicine, Genetics, Biology, Genotype, Gene
- MeSH
- animals, chickens, humans, gout, hyperuricemia, genetic predisposition to disease, uric acid, neoplasm proteins, alcohol drinking, smoking, life style, gene expression, eating, genotype, haplotypes, polymorphism, single nucleotide, alleles, meat, adult, aged, middle aged, female, male, glucose transport proteins, facilitative, atp binding cassette transporter, subfamily g, member 2
4 authors
From KR
- Hye Jeong YangKorea Food Research Institute
- Meiling LiuHoseo University
- Min Jung KimKorea Food Research Institute
- Sunmin Park · correspondingHoseo University
Abstract
We determined that a genetic haplotype increased the risk of hyperuricaemia and it interacted with lifestyle factors, including nutrients in 28,445 middle-aged Koreans. ABCG2_rs2231142, PKD2_rs2725220 and SLC2A9_rs3733591 were selected from GWAS based on hyperuricaemia (≥7 mg/dL; p = 6.88E-42, 1.56E-26 and 1.01E-20, respectively). Hyperuricaemia and gout were elevated by 3.93- and 3.23-fold, respectively, by the minor alleles as compared with the major alleles of the haplotype of the selected 3 SNPs after adjusting for covariates. The haplotype significantly interacted with alcohol, chicken and processed meat intakes, and smoking status in the hyperuricaemia risk (p = 0.002-0.007). Minor alleles of the haplotype had an association with hyperuricaemia as compared with major alleles particularly in high intakes of alcohol (2g/day), chicken (6.3g/day), and processed meat (3g/day) and smokers. In conclusion, people carrying minor alleles of the haplotype of SLC2A9_rs3733591, PKD2_rs2725220 and ABCG2_rs2231142 should avoid diets high in chicken and processed meat, alcohol drinking, and cigarette smoking to protect against hyperuricaemia risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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