Genetic susceptibility, dietary cholesterol intake, and plasma cholesterol levels in a Chinese population
Huo S, Sun L, Zong G, Song B, Zheng H, Jin Q, Li H, Lin X
Journal of lipid research · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Chinese Academy of Sciences
- Government
- Ministry of Science and Technology of the People's Republic of China
- Government
- Science and Technology Commission of Shanghai Municipality
- Government
- Shanghai Municipal Science and Technology
- Government
- Ministry of Science and Technology of China
- University or hospital
- Strategic Priority Research Program of the Chinese Academy of Sciences
- Grants
- Chinese Academy of Sciences (ZDBS-SSW-DQC-02); Chinese Academy of Sciences (2017SHZDZX01); National Natural Science Foundation of China (KJZD-EW-L14-2-2); National Natural Science Foundation of China (KSCX2-EW-R-10); National Natural Science Foundation of China (81700700); Chinese Academy of Sciences (KJZD-EW-L14-2-2); Ministry of Science and Technology of the People's Republic of China (2017YFC0909701); National Natural Science Foundation of China (KJZD-EW-L14); National Natural Science Foundation of China (81970684); Chinese Academy of Sciences (XDB38010300); Science and Technology Commission of Shanghai Municipality (2017SHZDZX01); National Natural Science Foundation of China (2017SHZDZX01); Chinese Academy of Sciences (KJZD-EW-L14); Ministry of Science and Technology of the People's Republic of China (2016YFC1304903); Chinese Academy of Sciences (KSCX2-EW-R-10)
Based on 7 listed funder(s).
Publication
- Published
- 2020-08-12 · J Lipid Res · vol. 61 · issue 11 · pp. 1504–1511
- Publisher
- Elsevier BV
- Cited
- 7 citations · more than 67% of similar papers · 0.5× the field average
- References
- 46 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Genetic Associations and Epidemiology · Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health
- Keywords
- Cholesterol, Quartile, Single-nucleotide polymorphism, Population, Internal medicine, Dietary Cholesterol, Endocrinology, Biology, Medicine, Genotype, Genetics, Gene, Environmental health, Confidence interval
- MeSH
- humans, cholesterol, cholesterol, dietary, risk factors, aged, middle aged, female, male, cholesterol, ldl, genetic variation, asian people
8 authors
From CN
- Shaofeng HuoShanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Liang Tso SunShanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Geng ZongShanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Boyu SongShanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- He ZhengShanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Qianlu JinShanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
Abstract
Accompanied with nutrition transition, non-HDL-C levels of individuals in Asian countries has increased rapidly, which has caused the global epicenter of nonoptimal cholesterol to shift from Western countries to Asian countries. Thus, it is critical to underline major genetic and dietary determinants. In the current study of 2,330 Chinese individuals, genetic risk scores (GRSs) were calculated for total cholesterol (TC; GRSTC, 57 SNPs), LDL-C (GRSLDL-C, 45 SNPs), and HDL-C (GRSHDL-C, 65 SNPs) based on SNPs from the Global Lipid Genetics Consortium study. Cholesterol intake was estimated by a 74-item food-frequency questionnaire. Associations of dietary cholesterol intake with plasma TC and LDL-C strengthened across quartiles of the GRSTC (effect sizes: -0.29, 0.34, 2.45, and 6.47; Pinteraction = 0.002) and GRSLDL-C (effect sizes: -1.35, 0.17, 5.45, and 6.07; Pinteraction = 0.001), respectively. Similar interactions with non-HDL-C were observed between dietary cholesterol and GRSTC (Pinteraction = 0.001) and GRSLDL-C (Pinteraction = 0.004). The adverse effects of GRSTC on TC (effect sizes across dietary cholesterol quartiles: 0.51, 0.82, 1.21, and 1.31; Pinteraction = 0.023) and GRSLDL-C on LDL-C (effect sizes across dietary cholesterol quartiles: 0.66, 0.52, 1.12, and 1.56; Pinteraction = 0.020) were more profound in those having higher cholesterol intake compared with those with lower intake. Our findings suggest significant interactions between genetic susceptibility and dietary cholesterol intake on plasma cholesterol profiles in a Chinese population.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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