Funded in part by Bayer Consumer Care AG, Basel, Switzerland
Multiple Micronutrients and Docosahexaenoic Acid Supplementation during Pregnancy: A Randomized Controlled Study
Massari M, Novielli C, Mandò C, Di Francesco S, Della Porta M, Cazzola R, Panteghini M, Savasi V, Maggini S, Schaefer E, Cetin I
Nutrients · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- University or hospital
- Università degli Studi di Milano
- Company
- Bayer Consumer Care AG, Basel, Switzerland
- Authors
- At least one author declares a financial tie to industry
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-08-13 · Nutrients · vol. 12 · issue 8 · p. 2432
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 40 citations · more than 90% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 71 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Fatty Acid Research and Health · Birth, Development, and Health · Infant Nutrition and Health
- Keywords
- Micronutrient, Docosahexaenoic acid, Pregnancy, Randomized controlled trial, Medicine, Obstetrics, Physiology, Biology, Internal medicine, Biochemistry, Fatty acid, Polyunsaturated fatty acid, Pathology, Genetics
- MeSH
- fetal blood, humans, docosahexaenoic acids, micronutrients, vitamin d, treatment outcome, prenatal care, nutritional status, fetal development, pregnancy, pregnancy trimesters, dietary supplements, adolescent, adult, infant, newborn, female, maternal nutritional physiological phenomena, young adult, biomarkers
11 authors
From IT, CH
- Maddalena MassariLuigi Sacco Hospital; ASST Fatebenefratelli Sacco
- Chiara NovielliLuigi Sacco Hospital
- Chiara MandòLuigi Sacco Hospital
- Stefania Di FrancescoASST Fatebenefratelli Sacco
- Matteo Giovanni Della PortaLuigi Sacco Hospital
- Roberta CazzolaLuigi Sacco Hospital
Abstract
Maternal dietary intake during pregnancy needs to meet increased nutritional demands to maintain metabolism and to support fetal development. Docosahexaenoic acid (DHA) is essential for fetal neuro-/visual development and in immunomodulation, accumulating rapidly within the developing brain and central nervous system. Levels available to the fetus are governed by the maternal diet. In this multicenter, parallel, randomized controlled trial, we evaluated once-daily supplementation with multiple micronutrients and DHA (i.e., multiple micronutrient supplementation, MMS) on maternal biomarkers and infant anthropometric parameters during the second and third trimesters of pregnancy compared with no supplementation. Primary efficacy endpoint: change in maternal red blood cell (RBC) DHA (wt% total fatty acids) during the study. Secondary variables: other biomarkers of fatty acid and oxidative status, vitamin D, and infant anthropometric parameters at delivery. Supplementation significantly increased RBC DHA levels, the omega-3 index, and vitamin D levels. Subscapular skinfold thickness was significantly greater with MMS in infants. Safety outcomes were comparable between groups. This first randomized controlled trial of supplementation with multiple micronutrients and DHA in pregnant women indicated that MMS significantly improved maternal DHA and vitamin D status in an industrialized setting-an important finding considering the essential roles of DHA and vitamin D.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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