Vitamin D status and outcomes for hospitalised older patients with COVID-19
Baktash V, Hosack T, Patel N, Shah S, Kandiah P, Van den Abbeele K, Mandal AKJ, Missouris CG
Postgraduate medical journal · 159 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-08-27 · Postgrad Med J · vol. 97 · issue 1149 · pp. 442–447
- Publisher
- Oxford University Press
- Cited
- 263 citations · more than 100% of similar papers · 30.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 29 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Vitamin D Research Studies · COVID-19 Clinical Research Studies · Vitamin C and Antioxidants Research
- Keywords
- Medicine, Vitamin D and neurology, vitamin D deficiency, Coronavirus disease 2019 (COVID-19), Internal medicine, Incidence (geometry), Prospective cohort study, Gastroenterology, Cohort study, Cohort, Disease
- MeSH
- humans, pneumonia, viral, vitamin d deficiency, vitamin d, fibrin fibrinogen degradation products, radiography, thoracic, hospitalization, geriatric assessment, severity of illness index, hospital mortality, predictive value of tests, aged, female, male, biomarkers, united kingdom, outcome assessment, health care, covid-19, sars-cov-2
8 authors
From GB, CY
- Vadir BaktashWexham Park Hospital; Frimley Health NHS Foundation Trust
- Tom HosackWexham Park Hospital; Frimley Health NHS Foundation Trust
- Nishil ZahariWexham Park Hospital; Frimley Health NHS Foundation Trust
- S.I. ShahWexham Park Hospital; Frimley Health NHS Foundation Trust
- Pirabakaran KandiahWexham Park Hospital; Frimley Health NHS Foundation Trust
- Koenraad Van den AbbeeleWexham Park Hospital; Frimley Health NHS Foundation Trust
Abstract
Purpose
Older adults are more likely to be vitamin D deficient. The aim of the study was to determine whether these patients have worse outcomes with COVID-19.
Methods
We conducted a prospective cohort study between 1 March and 30 April 2020 to assess the importance of vitamin D deficiency in older patients with COVID-19. The cohort consisted of patients aged ≥65 years presenting with symptoms consistent with COVID-19 (n=105). All patients were tested for serum 25-hydroxyvitamin D (25(OH)D) levels during acute illness. Diagnosis of COVID-19 was confirmed via viral reverse transcriptase PCR swab or supporting radiological evidence. COVID-19-positive arm (n=70) was sub-divided into vitamin D-deficient (≤30 nmol/L) (n=39) and -replete groups (n=35). Subgroups were assessed for disease severity using biochemical, radiological and clinical markers. Primary outcome was in-hospital mortality. Secondary outcomes were laboratory features of cytokine storm, thoracic imaging changes and requirement of non-invasive ventilation (NIV).
Results
COVID-19-positive arm demonstrated lower median serum 25(OH)D level of 27 nmol/L (IQR=20-47 nmol/L) compared with COVID-19-negative arm, with median level of 52 nmol/L (IQR=31.5-71.5 nmol/L) (p value=0.0008). Among patients with vitamin D deficiency, there was higher peak D-dimer level (1914.00 μgFEU/L vs 1268.00 μgFEU/L) (p=0.034) and higher incidence of NIV support and high dependency unit admission (30.77% vs 9.68%) (p=0.042). No increased mortality was observed between groups.
Conclusion
Older adults with vitamin D deficiency and COVID-19 may demonstrate worse morbidity outcomes. Vitamin D status may be a useful prognosticator.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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