Canola oil compared with sesame and sesame-canola oil on glycaemic control and liver function in patients with type 2 diabetes: A three-way randomized triple-blind cross-over trial
Raeisi-Dehkordi H, Amiri M, Zimorovat A, Moghtaderi F, Zarei S, Forbes SC, Salehi-Abargouei A
Diabetes/metabolism research and reviews · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-08-29 · Diabetes Metab Res Rev · vol. 37 · issue 5 · p. e3399
- Publisher
- Wiley
- Cited
- 27 citations · more than 93% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 65 works
- Access
- Paywalled
- Research areas
- Sesame and Sesamin Research · Fatty Acid Research and Health · Diet and metabolism studies
- Keywords
- Medicine, Internal medicine, Insulin resistance, Type 2 diabetes, Quantitative insulin sensitivity check index, Insulin, Diabetes mellitus, Canola, Liver function, Type 2 Diabetes Mellitus, Endocrinology, Gastroenterology, Insulin sensitivity, Biology, Food science
- MeSH
- liver, humans, sesamum, diabetes mellitus, type 2, insulin resistance, sesame oil, cross-over studies, female, male, rapeseed oil, glycemic control
7 authors
From IR, CA
- Hamidreza Raeisi‐DehkordiShahid Sadoughi University of Medical Sciences and Health Services
- Mojgan AmiriShahid Sadoughi University of Medical Sciences and Health Services
- Alireza ZimorovatShahid Sadoughi University of Medical Sciences and Health Services
- Fatemeh MoghtaderiShahid Sadoughi University of Medical Sciences and Health Services
- Sadegh ZareiRafsanjan University of Medical Sciences
- Scott C. ForbesBrandon University
Abstract
Background
This study aimed to compare the effects of sesame (SO), canola (CO), and sesame-canola (SCO: a blend) oils on glycaemic control markers and liver function enzymes in adults with type 2 diabetes.
Methods
In this randomized, triple-blind, three-way, cross-over clinical trial, participants replaced their usual oil with the intervention oils for 9 weeks. Serum fasting blood sugar, fasting serum insulin (FSI), insulin resistance (HOMA2-IR), beta-cell function (HOMA2-%B), insulin sensitivity (HOMA2-%S), quantitative insulin sensitivity check index (QUICKI), as well as serum liver function enzymes were measured at baseline and end of intervention periods.
Results
Ninety-two participants completed all treatment periods. After adjusting for confounders, all treatment oils resulted in significant improvements in FSI and HOMA2-%S (p < 0.05). SO and SCO led to favourable changes in HOMA2-IR and QUICKI (p < 0.05). Following CO and SCO, there was a significant decrease in HOMA2-%B (p < 0.05). The sex-stratified analysis revealed that FSI and HOMA2-IR were decreased after SO compared to CO in males (p = 0.024). Serum gamma-glutamyltransferase (GGT) was significantly lower following SO compared to CO in females (p = 0.02), however, the difference in change values was not significant (p = 0.058).
Conclusions
SO consumption appears to improve glycaemic control markers in males and serum GGT in females compared with CO in patients with type 2 diabetes (registration code: IRCT2016091312571N6).
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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