Egg consumption and cardiovascular risk: a dose-response meta-analysis of prospective cohort studies
Godos J, Micek A, Brzostek T, Toledo E, Iacoviello L, Astrup A, Franco OH, Galvano F, Martinez-Gonzalez MA, Grosso G
European journal of nutrition · 36 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Ministero della Salute
- University or hospital
- Università di Catania
- University or hospital
- Università degli Studi di Catania
- Grants
- Ministero della Salute (2751594)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-08-31 · Eur J Nutr · vol. 60 · issue 4 · pp. 1833–1862
- Publisher
- Springer Science+Business Media
- Cited
- 65 citations · more than 88% of similar papers · 2.1× the field average
- References
- 83 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress · Sodium Intake and Health
- Keywords
- Meta-analysis, Prospective cohort study, Medicine, Cohort study, Environmental health, Consumption (sociology), Internal medicine
- MeSH
- humans, cardiovascular diseases, risk factors, prospective studies, eggs, stroke, heart disease risk factors
10 authors
From IT, PL, ES, DK, CH, NL, US
- Justyna GodosOasi Maria SS; Istituti di Ricovero e Cura a Carattere Scientifico
- Agnieszka MicekJagiellonian University
- Tomasz BrzostekJagiellonian University
- Estefanía ToledoSpanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Universidad de Navarra
- Licia IacovielloUniversity of Insubria; Istituto Neurologico Mediterraneo
- Arne Vernon AstrupUniversity of Copenhagen
Abstract
Purpose
Cardiovascular disease (CVD) is a leading cause of mortality globally and is strongly influenced by dietary risk factors. The aim was to assess the association between egg consumption and risk of CVD risk/mortality, including coronary heart disease (CHD), stroke, and heart failure.
Methods
MEDLINE, Embase, and Web of Science databases were searched through April 2020 for prospective studies. Two independent reviewers screened and extracted the data through standardized methods. Size effects were calculated as summary relative risks (SRRs) in a dose-response fashion through random-effects meta-analyses.
Results
Thirty-nine studies including nearly 2 million individuals and 85,053 CHD, 25,103 stroke, 7536 heart failure, and 147,124 CVD cases were included. The summary analysis including 17 datasets from 14 studies conducted on CVD (incidence and/or mortality) showed that intake of up to six eggs per week is inversely associated with CVD events, when compared to no consumption [for four eggs per week, SRR = 0.95 (95% CI: 0.90; 1.00)]; a decreased risk of CVD incidence was observed for consumption of up to one egg per day [SRR = 0.94 (95% CI: 0.89; 0.99)]. The summary analysis for CHD incidence/mortality including 24 datasets from 16 studies showed a decreased risk up to two eggs per week [(SRR = 0.96 (95% CI: 0.91; 1.00)]. No associations were retrieved with risk of stroke. The summary analysis for heart failure risk including six datasets from four studies showed that intake of one egg per day was associated with increased risk raising for higher intakes compared to no consumption [for 1 egg per day, SRR = 1.15 (95% CI:1.02; 1.30)]. After considering GRADE criteria for strength of the evidence, it was rated low for all outcomes but stroke, for which it was moderate (yet referring to no risk).
Conclusion
There is no conclusive evidence on the role of egg in CVD risk, despite the fact that higher quality studies are warranted to obtain stronger evidence for a possible protection of CVD associated with moderate weekly egg consumption compared to no intake; equally, future studies may strengthen the evidence for increased heart failure risk associated with high regular egg consumption.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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