Music-listening regulates human microRNA expression
Nair PS, Raijas P, Ahvenainen M, Philips AK, Ukkola-Vuoti L, Järvelä I
Epigenetics · 30 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- Helsingin Yliopisto
- Nonprofit
- Wellcome Trust
- Government
- China Scholarship Council
- Government
- Medical Research Council
- Government
- Biotieteiden ja Ympäristön Tutkimuksen Toimikunta
- Nonprofit
- Wellcome Trust Center for Human Genetics
- University or hospital
- University of Helsinki
- Government
- MRC Hub
- Grants
- Wellcome Trust (91070); Medical Research Council (G0900747 91070); Wellcome Trust (G090074791070); Wellcome Trust (G0900747); Medical Research Council (090532/Z09/Z); Biotieteiden ja Ympäristön Tutkimuksen Toimikunta (13771); Wellcome Trust (090532); Wellcome Trust (090532/Z/09/Z); Wellcome Trust (090532/Z/09/); Wellcome Trust (090532/Z)
Based on 8 listed funder(s).
Publication
- Published
- 2020-09-01 · Epigenetics · vol. 16 · issue 5 · pp. 554–566
- Publisher
- Landes Bioscience
- Cited
- 53 citations · more than 97% of similar papers · 5.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 84 works
- Access
- Free to read
- Research areas
- Music Therapy and Health · Neuroscience and Music Perception · Noise Effects and Management
- Keywords
- Biology, microRNA, Active listening, Expression (computer science), Computational biology, Cell biology, Genetics, Gene, Communication, Psychology, Computer science
- MeSH
- central nervous system, humans, micrornas, dna methylation, gene expression regulation, down-regulation, music
6 authors
From FI
- Preethy Sasidharan NairUniversity of Helsinki
- Pirre RaijasEtelä-Karjalan sosiaali ja terveyspiiri
- Minna AhvenainenUniversity of Helsinki
- Anju K. PhilipsUniversity of Helsinki
- Liisa Ukkola‐VuotiUniversity of Helsinki
- Irma E. Järvelä · correspondingUniversity of Helsinki
Abstract
Music-listening and performance have been shown to affect human gene expression. In order to further elucidate the biological basis of the effects of music on the human body, we studied the effects of music-listening on gene regulation by sequencing microRNAs of the listeners (Music Group) and their controls (Control Group) without music exposure. We identified upregulation of six microRNAs (hsa-miR-132-3p, hsa-miR-361-5p, hsa-miR-421, hsa-miR-23a-3p, hsa-miR-23b-3p, hsa-miR-25-3p) and downregulation of two microRNAs (hsa-miR-378a-3p, hsa-miR-16-2-3p) in Music Group with high musical aptitude. Some upregulated microRNAs were reported to be responsive to neuronal activity (miR-132, miR-23a, miR-23b) and modulators of neuronal plasticity, CNS myelination, and cognitive functions like long-term potentiation and memory. miR-132 plays a critical role in regulating TAU protein levels and is important for preventing tau protein aggregation that causes Alzheimer's disease. miR-132 and DICER, upregulated after music-listening, protect dopaminergic neurons and are important for retaining striatal dopamine levels. Some of the transcriptional regulators (FOS, CREB1, JUN, EGR1, and BDNF) of the upregulated microRNAs were immediate early genes and top candidates associated with musical traits. BDNF and SNCA, co-expressed and upregulated in music-listening and music-performance, are both are activated by GATA2, which is associated with musical aptitude. Several miRNAs were associated with song-learning, singing, and seasonal plasticity networks in songbirds. We did not detect any significant changes in microRNA expressions associated with music education or low musical aptitude. Our data thereby show the importance of inherent musical aptitude for music appreciation and for eliciting the human microRNA response to music-listening.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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