Replacement of Red and Processed Meat With Other Food Sources of Protein and the Risk of Type 2 Diabetes in European Populations: The EPIC-InterAct Study
Ibsen DB, Steur M, Imamura F, Overvad K, Schulze MB, Bendinelli B, Guevara M, Agudo A, Amiano P, Aune D, Barricarte A, Ericson U, Fagherazzi G, Franks PW, Freisling H, Quiros JR, Grioni S, Heath AK, Huybrechts I, Katze V, Laouali N, Mancini F, Masala G, Olsen A, Papier K, Ramne S, Rolandsson O, Sacerdote C, Sánchez MJ, Santiuste C, Simeon V, Spijkerman AMW, Srour B, Tjønneland A, Tong TYN, Tumino R, van der Schouw YT, Weiderpass E, Wittenbecher C, Sharp SJ, Riboli E, Forouhi NG, Wareham NJ
Diabetes care · 47 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- World Health Organization
- Nonprofit
- Wellcome Trust
- Government
- National Institute for Health and Care Research
- Government
- European Commission
- Government
- Bundesministerium für Bildung und Forschung
- University or hospital
- Università degli Studi della Campania Luigi Vanvitelli
- Government
- Sixth Framework Programme
- Government
- Medical Research Council
- Government
- Regional Government of Navarre
- University or hospital
- Programma VALERE, University of Campania Luigi Vanvitelli.
- Government
- State of Brandenburg
- Government
- National Institute for Health Research (NIHR)
- University or hospital
- NIHR Biomedical Research Centre Cambridge: Nutrition, Diet, and Lifestyle Research Theme
- Government
- MRC Epidemiology Unit
- Government
- European Union Sixth Framework Programme
- Government
- German Ministry of Education and Research
- Grants
- Medical Research Council (IS-BRC-1215-20014); Medical Research Council (MC_UU_12015/1); Medical Research Council (MC_UU_12015/5); Medical Research Council (MC_UU_12015/5); Medical Research Council (MC_UU_12015); National Institute for Health and Care Research ([IS-BRC-1215-20014); Bundesministerium für Bildung und Forschung (82DZD00302); National Institute for Health and Care Research (BRC1215-20014); National Institute for Health and Care Research (MC_UU_12015/1); Medical Research Council (MR/M012190/1); National Institute for Health and Care Research (IS-BRC-1215); Medical Research Council (BRC-1215-20014); Medical Research Council (MC_UU_12015/1); Wellcome Trust (205212/Z/16/Z); National Institute for Health and Care Research (NF-SI-0617-10149); Sixth Framework Programme (LSHM_CT_2006_037197)
Based on 16 listed funder(s).
Publication
- Published
- 2020-08-31 · Diabetes Care · vol. 43 · issue 11 · pp. 2660–2667
- Publisher
- American Diabetes Association
- Cited
- 60 citations · more than 97% of similar papers · 6.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 38 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Agriculture Sustainability and Environmental Impact · Consumer Attitudes and Food Labeling
- Keywords
- Medicine, EPIC, Diabetes mellitus, Type 2 diabetes, Red meat, Environmental health, Processed meat, Type 1 diabetes, Food science, Endocrinology, Pathology, Biology
- MeSH
- milk, animals, humans, diabetes mellitus, type 2, diet, proportional hazards models, risk factors, follow-up studies, prospective studies, yogurt, seafood, aged, middle aged, europe, female, male, self report, red meat
43 authors
From DK, GB, DE, IT, ES, NO, SE, FR, LU, NL, US
- Daniel Borch Ibsen · correspondingAarhus University; University of Cambridge; MRC Epidemiology Unit
- Marinka SteurUniversity of Cambridge; MRC Epidemiology Unit
- Fumiaki ImamuraUniversity of Cambridge; MRC Epidemiology Unit
- Kim OvervadAarhus University; Aalborg University Hospital
- Matthias Bernd SchulzeUniversity of Potsdam; Deutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; German Institute of Human Nutrition; Heinrich Heine University Düsseldorf
- Benedetta BendinelliPiedmont Reference Center for Epidemiology and Cancer Prevention
Abstract
Objective
There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact.
Research design and methods
The European Prospective Investigation into Cancer (EPIC)-InterAct case cohort included 11,741 individuals with type 2 diabetes and a subcohort of 15,450 participants in eight countries. We modeled the replacement of self-reported red and processed meat with poultry, fish, eggs, legumes, cheese, cereals, yogurt, milk, and nuts. Country-specific hazard ratios (HRs) for incident type 2 diabetes were estimated by Prentice-weighted Cox regression and pooled using random-effects meta-analysis.
Results
There was a lower hazard for type 2 diabetes for the modeled replacement of red and processed meat (50 g/day) with cheese (HR 0.90, 95% CI 0.83-0.97) (30 g/day), yogurt (0.90, 0.86-0.95) (70 g/day), nuts (0.90, 0.84-0.96) (10 g/day), or cereals (0.92, 0.88-0.96) (30 g/day) but not for replacements with poultry, fish, eggs, legumes, or milk. If a causal association is assumed, replacing red and processed meat with cheese, yogurt, or nuts could prevent 8.8%, 8.3%, or 7.5%, respectively, of new cases of type 2 diabetes.
Conclusions
Replacement of red and processed meat with cheese, yogurt, nuts, or cereals was associated with a lower rate of type 2 diabetes. Substituting red and processed meat by other protein sources may contribute to the prevention of incident type 2 diabetes in European populations.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.