Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study
Ooi TC, Meramat A, Rajab NF, Shahar S, Ismail IS, Azam AA, Sharif R
Nutrients · 97 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Universiti Kebangsaan Malaysia
- Government
- Ministry of Education, Malaysia
- Grants
- Universiti Kebangsaan Malaysia (GUP-2018)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-08-30 · Nutrients · vol. 12 · issue 9 · p. 2644
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 132 citations · more than 97% of similar papers · 5.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 81 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Nutritional Studies and Diet
- Keywords
- Cognitive decline, Internal medicine, Medicine, Malondialdehyde, Cognition, Ketone bodies, Weight loss, Dementia, Physiology, Endocrinology, Oxidative stress, Gerontology, Metabolism, Disease, Obesity, Psychiatry
- MeSH
- humans, dna damage, inflammation, fasting, geriatric assessment, cohort studies, follow-up studies, feeding behavior, cognition, oxidative stress, aged, malaysia, female, male, metabolomics, cognitive dysfunction
7 authors
From MY
- Theng Choon OoiNational University of Malaysia
- Asheila MeramatSultan Zainal Abidin University
- Nor Fadilah RajabNational University of Malaysia
- Suzana ShaharNational University of Malaysia
- Intan Safinar IsmailUniversiti Putra Malaysia
- Amalina Ahmad AzamUniversiti Putra Malaysia
Abstract
Intermittent fasting (IF) refers to various dietary regimens that cycle between a period of non-fasting and a period of total fasting. This study aimed to determine the effects of IF on cognitive function among elderly individuals who practice IF who have mild cognitive impairment (MCI). A total of 99 elderly subjects with MCI of Malay ethnicity without any terminal illness were recruited from a larger cohort study, LRGS TUA. The subjects were divided into three groups, comprising those who were regularly practicing IF (r-IF), irregularly practicing IF (i-IF), and non-fasters (n-IF). Upon 36 months of follow-up, more MCI subjects in the r-IF group reverted to successful aging with no cognitive impairment and diseases (24.3%) compared to those in i-IF (14.2%) and n-IF groups (3.7%). The r-IF group's subjects exhibited significant increment in superoxide dismutase (SOD) activity and reduction in body weight, levels of insulin, fasting blood glucose, malondialdehyde (MDA), C-reactive protein (CRP), and DNA damage. Moreover, metabolomics analysis showed that IF may modulate cognitive function via various metabolite pathways, including the synthesis and degradation of ketone bodies, butanoate metabolism, pyruvate metabolism, and glycolysis and gluconeogenesis pathways. Overall, the MCI-afflicted older adults who practiced IF regularly had better cognitive scores and reverted to better cognitive function at 36 months follow-up.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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