Semen Creatine and Creatine Kinase Activity as an Indicator of Sperm Quality
Nasrallah F, Hammami MB, Omar S, Aribia HB, Sanhaji H, Feki M
Clinical laboratory · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-01-01 · Clin Lab · vol. 66 · issue 09/2020
- Publisher
- Clinical Laboratory Publications
- Cited
- 24 citations · more than 86% of similar papers · 2.0× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Sperm and Testicular Function · Chromium effects and bioremediation · Iron Metabolism and Disorders
- Keywords
- Semen, Creatine kinase, Sperm quality, Sperm, Andrology, Semen quality, Creatine, Medicine, Chemistry, Internal medicine
- MeSH
- spermatozoa, semen, humans, infertility, male, creatine, creatine kinase, sperm motility, child, male
6 authors
- Fahmi Nasrallah
- Mohamed Ali Hammami
- Souheil Omar
- Hamadi Aribia
- Haïfa Sanhaji
- Moncef Feki
Abstract
Background
The role of creatine (Cr) and creatine kinase (CK) in sperm function remains unclear. The study aimed to assess Cr and CK in seminal plasma and test their association with sperm characteristics.
Methods
The study included 62 males with couple's infertility and 26 males who have already fathered children. Semen Cr and CK were assessed by GC-MS and spectrophotometry, respectively. Seminogram parameters were analyzed using conventional methods.
Results
Cytomorphologic analysis of sperm showed normozoospermia in 53 men (NS) and an asthenozoospermia (AS) in 35 men. Semen Cr was high with no significant difference between the two groups (791 ± 342 and 744 ± 422 µmol/L, respectively). However, semen CK activity was higher in AS group (1,360 ± 1,050 vs. 830 ± 580 U/L, p = 0.013). Semen Cr was positively related to progressive motility (r = 0.284; p = 0.010). Semen CK was negatively correlated with sperm concentration (r = -0.29; p = 0.01), progressive motility (r = -0.26; p = 0.03), and the percentage of abnormal spermatozoa (r = -0.28; p = 0.02).
Conclusions
Semen contains high amounts of Cr and increased CK activity. Low semen Cr is associated with reduced sperm motility while high CK activity is associated with poor sperm quality. The findings suggest that Cr is of importance for sperm metabolism and that Cr supplementation could be useful in males with poor quality sperm.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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