Dietary Rapeseed Oil Supplementation Reduces Hepatic Steatosis in Obese Men-A Randomized Controlled Trial
Kruse M, Kemper M, Gancheva S, Osterhoff M, Dannenberger D, Markgraf D, Machann J, Hierholzer J, Roden M, Pfeiffer AFH
Molecular nutrition & food research · 19 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-09-28 · Mol Nutr Food Res · vol. 64 · issue 21 · p. e2000419
- Publisher
- Wiley
- Cited
- 26 citations · more than 87% of similar papers · 1.9× the field average
- References
- 61 works
- Access
- Open access (repository copy) · CC-BY
- Research areas
- Liver Disease Diagnosis and Treatment · Fatty Acid Research and Health · Phytoestrogen effects and research
- Keywords
- Internal medicine, Steatosis, Fatty liver, Endocrinology, Medicine, Polyunsaturated fatty acid, Lipid metabolism, Obesity, Fatty acid, Chemistry, Biochemistry, Disease
- MeSH
- liver, humans, insulin resistance, obesity, enzymes, lipids, fatty acids, glucose clamp technique, body composition, energy intake, dietary supplements, adult, aged, middle aged, male, non-alcoholic fatty liver disease, olive oil, rapeseed oil
10 authors
From DE
- Michael W. Kruse · correspondingGerman Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
- Margrit KemperDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; German Institute of Human Nutrition; Heinrich Heine University Düsseldorf; Charité - Universitätsmedizin Berlin
- Sofiya GanchevaDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Martin A. OsterhoffGerman Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
- Dirk DannenbergerResearch Institute for Farm Animal Biology (FBN)
- Daniel F. MarkgrafDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
Abstract
Scope
Effective treatment for obesity associated non-alcoholic fatty liver disease (NAFLD) is limited. Dietary supplementation of n-3 polyunsaturated fatty acids, specifically alpha linolenic acid (ALA), can resolve intrahepatic lipid content (IHL). This study investigates the effect of daily supplementation of either refined rapeseed (RA), containing high amounts of ALA, or refined olive (OL) oil on IHL and glucose metabolism in NAFLD patients.
Methods and results
27 obese men consumed an isocaloric diet including either 50 g of RA or OL daily for 8 weeks. Hepatic proton magnetic resonance spectroscopy, hyperinsulinemic-euglycemic clamp studies and blood tests are performed before and at the end of the study. At 8 weeks a significant reduction in IHL is observed for RA (13.1 ± 1.6 before versus 11.1 ± 1.6% after intervention) versus OL (13.3 ± 2.5 before versus 15.7 ± 2.7% after intervention). For RA, a 21% reduction (P < 0.02) in serum free fatty acids (FFA) and a 1.68-fold increase (P = 0.03) of serum interleukin-6 (IL-6) is observed after 8 weeks.
Conclusion
RA has a beneficial effect on hepatic lipid metabolism as shown by reduced IHL and serum FFA. RA induced IL-6 production seems to be liver protective confirming previous results.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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