Vitamin D Deficiency and Outcome of COVID-19 Patients
Radujkovic A, Hippchen T, Tiwari-Heckler S, Dreher S, Boxberger M, Merle U
Nutrients · 267 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2020-09-10 · Nutrients · vol. 12 · issue 9 · p. 2757
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 450 citations · more than 100% of similar papers · 48.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 25 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · COVID-19 Clinical Research Studies
- Keywords
- Medicine, vitamin D deficiency, Vitamin D and neurology, Internal medicine, Coronavirus disease 2019 (COVID-19), Single Center, Clinical endpoint, Disease, Pediatrics, Infectious disease (medical specialty), Randomized controlled trial
- MeSH
- humans, pneumonia, viral, coronavirus infections, vitamin d deficiency, vitamin d, prognosis, hospitalization, severity of illness index, retrospective studies, prospective studies, nutritional status, aged, middle aged, germany, female, male, pandemics, betacoronavirus, covid-19, sars-cov-2
6 authors
From DE
- Aleksandar RadujkovicHeidelberg University
- Theresa HippchenHeidelberg University
- Shilpa Tiwari‐HecklerHeidelberg University
- Saida DreherHeidelberg University
- Monica BoxbergerHeidelberg University
- Uta Merle · correspondingHeidelberg University
Abstract
Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level p p < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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