Funded in part by U.S. Highbush Blueberry Council
Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers
Ntemiri A, Ghosh TS, Gheller ME, Tran TTT, Blum JE, Pellanda P, Vlckova K, Neto MC, Howell A, Thalacker-Mercer A, O'Toole PW
Nutrients · 46 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- Government
- National Science Foundation
- Government
- Food Institutional Research Measure
- Industry group
- U.S. Highbush Blueberry Council
- Government
- Department of Agriculture, Food and the Marine, Ireland
- Government
- Science Foundation Ireland
- Government
- National Science Foundation Graduate Research Fellowship Program
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Science Foundation Graduate Research Fellowship Program (DGE-1650441); Science Foundation Ireland (12/RC/); Science Foundation Ireland (12/RC/2273_P2); National Science Foundation (1650441); National Science Foundation (DGE-165-0441)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-09-12 · Nutrients · vol. 12 · issue 9 · p. 2800
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 71 citations · more than 90% of similar papers · 2.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 107 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Gut microbiota and health · Nutritional Studies and Diet · Phytochemicals and Antioxidant Activities
- Keywords
- Polyphenol, Bioconversion, Food science, Gut flora, Feces, Microbiome, Biology, Bacteria, Proanthocyanidin, Sugar, Biochemistry, Antioxidant, Chemistry, Microbiology, Fermentation
- MeSH
- colon, feces, humans, anthocyanins, flavonols, glycosides, antioxidants, pilot projects, fermentation, oxidative stress, models, anatomic, adult, aged, female, young adult, polyphenols, healthy volunteers, gastrointestinal microbiome, blueberry plants
11 authors
From IE, US
- Alexandra NtemiriUniversity College Cork; APC Microbiome Institute
- Tarini Shankar GhoshUniversity College Cork; APC Microbiome Institute
- Molly E. GhellerCornell University
- Tam T. T. TranUniversity College Cork; APC Microbiome Institute
- Jamie BlumCornell University
- Paola PellandaUniversity College Cork; APC Microbiome Institute
Abstract
Blueberry (BB) consumption is linked to improved health. The bioconversion of the polyphenolic content of BB by fermentative bacteria in the large intestine may be a necessary step for the health benefits attributed to BB consumption. The identification of specific gut microbiota taxa that respond to BB consumption and that mediate the bioconversion of consumed polyphenolic compounds into bioactive forms is required to improve our understanding of how polyphenols impact human health. We tested the ability of polyphenol-rich fractions purified from whole BB-namely, anthocyanins/flavonol glycosides (ANTH/FLAV), proanthocyanidins (PACs), the sugar/acid fraction (S/A), and total polyphenols (TPP)-to modulate the fecal microbiota composition of healthy adults in an in vitro colon system. In a parallel pilot study, we tested the effect of consuming 38 g of freeze-dried BB powder per day for 6 weeks on the fecal microbiota of 17 women in two age groups (i.e., young and older). The BB ingredients had a distinct effect on the fecal microbiota composition in the artificial colon model. The ANTH/FLAV and PAC fractions were more effective in promoting microbiome alpha diversity compared to S/A and TPP, and these effects were attributed to differentially responsive taxa. Dietary enrichment with BB resulted in a moderate increase in the diversity of the microbiota of the older subjects but not in younger subjects, and certain health-relevant taxa were significantly associated with BB consumption. Alterations in the abundance of some gut bacteria correlated not only with BB consumption but also with increased antioxidant activity in blood. Collectively, these pilot data support the notion that BB consumption is associated with gut microbiota changes and health benefits.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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