Funded in part by Novo Nordisk, Novo Nordisk Fonden
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
Lundell LS, Parr EB, Devlin BL, Ingerslev LR, Altıntaş A, Sato S, Sassone-Corsi P, Barrès R, Zierath JR, Hawley JA
Nature communications · 109 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Industry funded
- Company
- Novo Nordisk
- Government
- Vetenskapsrådet
- Company
- Novo Nordisk Fonden
- University or hospital
- NNF Center for Basic Metabolic Research
- Grants
- Novo Nordisk Fonden (NNF18CC003490); Novo Nordisk Fonden (NNF14OC0011493); Vetenskapsrådet (2015-00165); Vetenskapsrådet (NNF14OC0011493)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-09-16 · Nat Commun · vol. 11 · issue 1 · p. 4643
- Publisher
- Nature Portfolio
- Cited
- 142 citations · more than 99% of similar papers · 8.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Keywords
- Metabolite, Transcriptome, Amino acid, Endocrinology, Internal medicine, Biology, Gene expression, Transporter, Skeletal muscle, CLOCK, Metabolism, Gene, Biochemistry, Medicine
- MeSH
- muscle, skeletal, humans, lipids, amino acids, fasting, cross-over studies, gene expression, circadian rhythm, adult, male, overweight, lipid metabolism, circadian clocks
10 authors
From DK, AU, US, SE
- Leonidas S. LundellUniversity of Copenhagen; Novo Nordisk Foundation
- Evelyn B. ParrAustralian Catholic University
- Brooke L. DevlinAustralian Catholic University
- Lars Roed IngerslevUniversity of Copenhagen; Novo Nordisk Foundation
- Ali AltıntaşUniversity of Copenhagen; Novo Nordisk Foundation
- Shogo SatoUniversity of California, Irvine
Abstract
Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated skeletal muscle and serum metabolic and transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day-1) and extended feeding (EXF, 15 h day-1) in a randomised cross-over design (trial registration: ACTRN12617000165381). Here we show that muscle core clock gene expression was similar after both interventions. TRF increases the amplitude of oscillating muscle transcripts, but not muscle or serum metabolites. In muscle, TRF induces rhythmicity of several amino acid transporter genes and metabolites. In serum, lipids are the largest class of periodic metabolites, while the majority of phase-shifted metabolites are amino acid related. In conclusion, short-term TRF in overweight men affects the rhythmicity of serum and muscle metabolites and regulates the rhythmicity of genes controlling amino acid transport, without perturbing core clock gene expression.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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