Highland Barley Whole Grain (Hordeum vulgare L.) Ameliorates Hyperlipidemia by Modulating Cecal Microbiota, miRNAs, and AMPK Pathways in Leptin Receptor-Deficient db/db Mice
Deng N, He Z, Guo R, Zheng B, Li T, Liu RH
Journal of agricultural and food chemistry · 34 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Higher Education Discipline Innovation Project
- Government
- Basic and Applied Basic Research Foundation of Guangdong Province
- Government
- the Guangzhou Innovation Leading Talent Project
- Government
- the Innovative Leading Talents Project of Guangzhou Development Zone
- Nonprofit
- the 111 Project
- Government
- the Guangdong Basic and Applied Basic Research Foundation
- Government
- Natural Science Foundation of Guangdong Province, China
- Grants
- Basic and Applied Basic Research Foundation of Guangdong Province (2020A1515011376); Higher Education Discipline Innovation Project (B1701 8)
Based on 7 listed funder(s).
Publication
- Published
- 2020-09-27 · J Agric Food Chem · vol. 68 · issue 42 · pp. 11735–11746
- Publisher
- American Chemical Society
- Cited
- 47 citations · more than 90% of similar papers · 2.3× the field average
- References
- 45 works
- Access
- Paywalled
- Research areas
- Gut microbiota and health · Metabolomics and Mass Spectrometry Studies · Nutrition, Genetics, and Disease
- Keywords
- AMPK, Hyperlipidemia, Fatty acid synthase, Biology, Endocrinology, Internal medicine, Gut flora, Biochemistry, Lipid metabolism, Protein kinase A, Kinase, Medicine
- MeSH
- cecum, liver, animals, mice, knockout, humans, mice, bacteria, hordeum, seeds, disease models, animal, micrornas, male, sterol regulatory element binding protein 1, hyperlipidemias, receptors, leptin, amp-activated protein kinases, fatty acid synthases, gastrointestinal microbiome
6 authors
From CN, US
- Na DengSouth China University of Technology
- Ziqian HeSouth China University of Technology
- Ruixue GuoGuangdong Pharmaceutical University
- Bisheng Zheng · correspondingSouth China University of Technology
- Li TongCornell University
- Rui Hai Liu · correspondingCornell University
Abstract
The mechanisms of highland barley whole grain (BWG) with rich phenolics on obese db/db mice were investigated in this study. Oral consumption of BWG reduced food intake, body weight, organ/body weight indexes of liver and fat, levels of serum and hepatic lipids, liver injury, and oxidative stress. Furthermore, BWG recovered the disorder of cecal microbiota by augmenting the Bacteroidetes/Firmicutes ratio and Alistipes abundance and decreasing the abundances of Bacteroides and Desulfovibrionaceae to modulate lipid metabolism-related genes. BWG inhibited fatty acid biosynthesis via upregulating the phosphorylation of AMP-activated protein kinase α, while downregulating sterol regulatory element binding protein-1c, fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 levels. BWG also significantly downregulated miRNA-122, miRNA-33, miRNA-34a, and miRNA-206 levels. Accordingly, BWG exhibited hypolipidemic potential through modulating cecal microbiota, AMPK/SREBP-1c/FAS pathway, and related miRNAs, triggering the alleviation of dyslipidemia. These findings suggested BWG as an effective candidate to ameliorate the symptoms of hyperlipidemia.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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