The Effects of Music Intervention on Pallidum-DMN Circuit of Schizophrenia
Yao Y, He H, Duan M, Li S, Li C, Chen X, Yao G, Chang X, Shu H, Wang H, Luo C
BioMed research international · 13 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Sichuan Province Science and Technology Support Program
- Grants
- National Natural Science Foundation of China (S17013); National Natural Science Foundation of China (Q19028); National Natural Science Foundation of China (2019YJ0651); Sichuan Province Science and Technology Support Program (2019YJ0179); National Natural Science Foundation of China (2016HH0005); Sichuan Province Science and Technology Support Program (2016HH0005); National Natural Science Foundation of China (2019YJ0179); National Natural Science Foundation of China (61761166001); National Natural Science Foundation of China (81471638)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-01-01 · Biomed Res Int · vol. 2020 · issue 1 · p. 4107065
- Publisher
- Hindawi Publishing Corporation
- Cited
- 17 citations · more than 67% of similar papers · 0.7× the field average
- References
- 50 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Functional Brain Connectivity Studies · Neuroscience and Music Perception · Advanced Neuroimaging Techniques and Applications
- Keywords
- Functional magnetic resonance imaging, Schizophrenia (object-oriented programming), Psychology, Striatum, Globus pallidus, Audiology, Neuroscience, Resting state fMRI, Hippocampus, Ventral striatum, Anterior cingulate cortex, Psychiatry, Medicine, Cognition, Basal ganglia, Central nervous system
- MeSH
- cerebellum, gyrus cinguli, hippocampus, globus pallidus, neural pathways, humans, antipsychotic agents, magnetic resonance imaging, brain mapping, longitudinal studies, schizophrenia, rest, music, adult, middle aged, female, male
11 authors
From CN
- Yutong YaoUniversity of Electronic Science and Technology of China
- Hui He · correspondingUniversity of Electronic Science and Technology of China
- Mingjun Duan · correspondingUniversity of Electronic Science and Technology of China
- Shicai LiUniversity of Electronic Science and Technology of China
- Buwen ChengUniversity of Electronic Science and Technology of China
- Xi ChenUniversity of Electronic Science and Technology of China
Abstract
Music intervention has been applied to improve symptoms of schizophrenic subjects as a complementary treatment in medicine. Although the psychiatric symptoms, especially for motivation and emotion, could be increased in schizophrenia, the underlying neural mechanisms remain poorly understood. We employed a longitudinal study to measure the alteration of striatum functional networks in schizophrenic subjects undergoing Mozart music listening using resting-state functional magnetic resonance imaging (fMRI). Forty-five schizophrenic inpatients were recruited and randomly assigned to two groups. Under the standard care with antipsychotic medication, one group received music intervention for 1 month and the other group is set as control. Both schizophrenic groups were compared to healthy subjects. Resting-state fMRI was acquired from schizophrenic subjects at baseline and after one-month music intervention and from healthy subjects at baseline. Striatum network was assessed through seed-based static and dynamic functional connectivity (FC) analyses. After music intervention, increased static FC was observed between pallidum and ventral hippocampus in schizophrenic subjects. Increased dynamic FCs were also found between pallidus and subregions of default mode network (DMN), including cerebellum crus and posterior cingulate cortex. Moreover, static pallidus-hippocampus FC increment was positively correlated with the improvement of negative symptoms in schizophrenic subjects. Together, these findings provided evidence that music intervention might have an effect on the FC of the striatum-DMN circuit and might be related to the remission of symptoms of schizophrenia.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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