An Almond-Based Low Carbohydrate Diet Improves Depression and Glycometabolism in Patients with Type 2 Diabetes through Modulating Gut Microbiota and GLP-1: A Randomized Controlled Trial
Ren M, Zhang H, Qi J, Hu A, Jiang Q, Hou Y, Feng Q, Ojo O, Wang X
Nutrients · 107 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Science and Technology Program of Suzhou
- Government
- Suzhou Science and Technology Project, China
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-10-03 · Nutrients · vol. 12 · issue 10 · p. 3036
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 144 citations · more than 98% of similar papers · 7.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 59 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nuts composition and effects · Diet and metabolism studies · Agriculture Sustainability and Environmental Impact
- Keywords
- Type 2 diabetes, Gut flora, Depression (economics), Medicine, Internal medicine, Type 2 Diabetes Mellitus, Randomized controlled trial, Diabetes mellitus, Endocrinology, Immunology
- MeSH
- feces, humans, diabetes mellitus, type 2, blood glucose, treatment outcome, fasting, prospective studies, depression, aged, female, male, diet, carbohydrate-restricted, glucagon-like peptide 1, gastrointestinal microbiome, prunus dulcis, glycemic control, glycated hemoglobin
9 authors
From CN, US, GB
- Mengxiao RenSoochow University
- Huaiyu ZhangUniversity of California, San Francisco
- Jindan QiSoochow University
- Anni HuSoochow University
- Qing JiangSoochow University
- Yunying HouSoochow University
Abstract
Background
Alow carbohydrate diet (LCD) is more beneficial for the glycometabolism in type 2 diabetes (T2DM) and may be effective in reducing depression. Almond, which is a common nut, has been shown to effectively improve hyperglycemia and depression symptoms. This study aimed to determine the effect of an almond-based LCD (a-LCD) on depression and glycometabolism, as well as gut microbiota and fasting glucagon-like peptide 1 (GLP-1) in patients with T2DM.
Methods
This was a randomized controlled trial which compared an a-LCD with a low-fat diet (LFD). Forty-five participants with T2DM at a diabetes club and the Endocrine Division of the First and Second Affiliated Hospital of Soochow University between December 2018 to December 2019 completed each dietary intervention for 3 months, including 22 in the a-LCD group and 23 in the LFD group. The indicators for depression and biochemical indicators including glycosylated hemoglobin (HbA1c), gut microbiota, and GLP-1 concentration were assessed at the baseline and third month and compared between the two groups.
Results
A-LCD significantly improved depression and HbA1c (p Roseburia, Ruminococcus and Eubacterium. The GLP-1 concentration in the a-LCD group was higher than that in the LFD group (p <0.05).
Conclusions
A-LCD could exert a beneficial effect on depression and glycometabolism in patients with T2DM. We speculate that the role of a-LCD in improving depression in patients with T2DM may be associated with it stimulating the growth of SCFAs-producing bacteria, increasing SCFAs production and GPR43 activation, and further maintaining GLP-1 secretion. In future studies, the SCFAs and GPR43 activation should be further examined.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.