Intake of dietary fibre, red and processed meat and risk of late-onset Chronic Inflammatory Diseases: A prospective Danish study on the "diet, cancer and health" cohort
Rubin KH, Rasmussen NF, Petersen I, Kopp TI, Stenager E, Magyari M, Hetland ML, Bygum A, Glintborg B, Andersen V
International journal of medical sciences · 24 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2020-01-01 · Int J Med Sci · vol. 17 · issue 16 · pp. 2487–2495
- Publisher
- Ivyspring International Publisher
- Cited
- 28 citations · more than 89% of similar papers · 2.2× the field average
- References
- 70 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Nutrition, Genetics, and Disease · Consumer Attitudes and Food Labeling
- Keywords
- Danish, Medicine, Prospective cohort study, Red meat, Dietary fibre, Cohort, Cohort study, Cancer, Internal medicine, Environmental health, Food science, Pathology, Biology
- MeSH
- intestinal mucosa, humans, chronic disease, inflammation, diet surveys, risk assessment, risk factors, prospective studies, feeding behavior, age of onset, dietary fiber, middle aged, denmark, female, male, protective factors, gastrointestinal microbiome, red meat
10 authors
From DK
- Katrine Hass RubinUniversity of Southern Denmark
- Nathalie Fogh RasmussenSygehus Sønderjylland
- Inge PetersenUniversity of Southern Denmark
- Tine Iskov KoppUniversity of Southern Denmark; Copenhagen University Hospital; Rigshospitalet; Danish Multiple Sclerosis Center; Danish Cancer Society
- Egon StenagerUniversity of Southern Denmark; Hospital South West Jutland; Sygehus Sønderjylland
- Melinda MagyariUniversity of Southern Denmark; Copenhagen University Hospital; Rigshospitalet; Danish Multiple Sclerosis Center
Abstract
Background: Human and animal studies support the involvement of diet in the development of CID -chronic inflammatory diseases such as inflammatory bowel disease, psoriasis, rheumatoid arthritis, psoriatic arthritis, and multiple sclerosis. Objective: This cohort study aimed to investigate the association between intake of fibre, red and processed meat, and occurrence of late-onset CID (50+ years of age) in the DCH: Danish Diet, Cancer and Health cohort. We hypothesised that risk of late-onset CID would be lower among those with high intake of fibre and/or low intake of meat compared to individuals with low fibre and/or high meat intake. Methods: The DCH recruited 56,468 individuals, aged 50-64 years, between 1993 and 1997. At recruitment, diet intake was registered using food frequency questionnaires as well as lifestyle factors in 56,075 persons. Exposure variables were generated as sex-adjusted tertiles of fibre and meat (g/day). Development of CIDs was identified in national registries. Hazard ratios (HR) of late-onset CIDs (adjusted for age, sex, energy intake, alcohol, smoking, education, comorbidity, and civil status) were estimated for all three exposure variables. Results: During follow-up of 1,123,754 years (median (Interquartile range) = 22.2 (20.1-23.1)), 1,758 (3.1%) participants developed at least one CID. The adjusted HRs for developing CID (low fibre 1.04 [0.89-1.22] and medium fibre 1.04 [0.91-1.18] (high fibre as reference), and medium meat 0.96 [0.86-1.09] and high meat 0.94 [0.82-1.07] (low meat as reference)) or the individual diseases were not statistically significant. Conclusion: This large study did not support that a high intake of fibre and/or a low intake of meat had a high impact on the risk of late-onset CID.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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