A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study
Tsolaki M, Lazarou E, Kozori M, Petridou N, Tabakis I, Lazarou I, Karakota M, Saoulidis I, Melliou E, Magiatis P
Journal of Alzheimer's disease : JAD · 65 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-10-09 · J Alzheimers Dis · vol. 78 · issue 2 · pp. 801–817
- Publisher
- IOS Press
- Cited
- 86 citations · more than 96% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 63 works
- Access
- Paywalled
- Research areas
- Edible Oils Quality and Analysis · Nutritional Studies and Diet · Nuts composition and effects
- Keywords
- Olive oil, Mediterranean diet, Randomized controlled trial, Cognition, Medicine, Cognitive impairment, Cognitive decline, Internal medicine, Neuropsychology, Verbal fluency test, Effects of sleep deprivation on cognitive performance, Gastroenterology, Dementia, Psychiatry, Food science, Disease, Biology
- MeSH
- humans, phenols, magnetic resonance spectroscopy, cohort studies, longitudinal studies, prospective studies, pilot projects, double-blind method, neuropsychological tests, diet, mediterranean, aged, aged, 80 and over, middle aged, greece, female, male, olive oil, cognitive dysfunction
10 authors
From GR
- Magda Tsolaki · correspondingAristotle University of Thessaloniki; AHEPA University Hospital; Greek Association of Alzheimer's Disease and Related Disorders
- Eftychia LazarouGreek Association of Alzheimer's Disease and Related Disorders
- Mahi KozoriGreek Association of Alzheimer's Disease and Related Disorders
- Niki PetridouGreek Association of Alzheimer's Disease and Related Disorders
- Irene-Maria TabakisAristotle University of Thessaloniki; AHEPA University Hospital
- Ioulietta LazarouAristotle University of Thessaloniki; AHEPA University Hospital
Abstract
Background
Extra virgin olive oil (EVOO) constitutes a natural compound with high protection over cognitive function.
Objective
To investigate for the first time the effect of Greek High Phenolic Early Harvest Extra Virgin Olive Oil (HP-EH-EVOO) versus Moderate Phenolic (MP-EVOO) and Mediterranean Diet (MeDi) in people with mild cognitive impairment (MCI).
Methods
We conducted a randomized prospective study so as to examine the HP-EH-EVOO and MP-EVOO versus MeDi in MCI. Genetic predisposition (APOEɛ4) to Alzheimer's disease (AD) was tested and an extensive neuropsychological battery was administered at baseline and after 12 months. Each participant was randomized and assigned one of three groups: 1) Group 1 received the HP-EH-EVOO (50 mL/day); 2) Group 2 received the MP-EVOO (50 mL/day), and 3) Group 3 received only the MeDi instructions.
Results
Better follow-up performance was found in Group 1 compared to Group 2 and Group 3 in the almost all cognitive domains. Moreover, Group 2 showed also significant improvement compared to Group 3 in ADAS-cog (p = 0.001) and MMSE (p = 0.05), whereas Group 3 exhibited worse or similar to baseline performance in almost all domains. In particular, Group 1 and Group 2 had better outcomes with regards to ADAS-cog (p = 0.003), Digit Span (p = 0.006), and Letter fluency (p = 0.003). Moreover, there was a significant difference (p = 0.001) in the presence of APOEɛ4 between the Groups 1 and 2 versus Group 3.
Conclusion
Long-term intervention with HP-EH-EVOO or MP-EVOO was associated with significant improvement in cognitive function compared to MeDi, independent of the presence of APOEɛ4.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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