Leukocyte Activation and Antioxidative Defense Are Interrelated and Moderately Modified by n-3 Polyunsaturated Fatty Acid-Enriched Eggs Consumption-Double-Blind Controlled Randomized Clinical Study
Mihalj M, Stupin A, Kolobarić N, Bujak IT, Matić A, Kralik Z, Jukić I, Stupin M, Drenjančević I
Nutrients · 10 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- European Structural and Investment Funds grant for the Croatian National Scientific Center of Excellence for Personalized Health Care, University of Josip Juraj Strossmayer Osijek
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-10-13 · Nutrients · vol. 12 · issue 10 · p. 3122
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 13 citations · more than 75% of similar papers · 1.0× the field average
- References
- 70 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Fatty Acid Research and Health · Eicosanoids and Hypertension Pharmacology · Cardiovascular Disease and Adiposity
- Keywords
- Polyunsaturated fatty acid, Oxidative stress, Internal medicine, Endothelium, Biology, Endocrinology, Food science, Fatty acid, Biochemistry, Medicine
- MeSH
- endothelium, vascular, leukocytes, humans, fatty acids, omega-3, antioxidants, double-blind method, food analysis, lymphocyte activation, eating, eggs, adult, female, male, nutritional physiological phenomena, young adult
9 authors
From HR
- Martina MihaljUniversity of Osijek
- Ana StupinUniversity of Osijek
- Nikolina KolobarićUniversity of Osijek
- Ivana Tartaro BujakUniversity of Zagreb
- Anita MatićUniversity of Osijek
- Zlata KralikUniversity of Osijek
Abstract
This placebo-controlled, double-blind, randomized, interventional study investigated the effects of low/intermediate doses of n-3 polyunsaturated fatty acids (PUFAs) on the endothelial function, markers of leukocyte activation, and oxidative status following dietary intake of n-3 PUFA-enriched hen eggs in young healthy individuals. Twenty young healthy adults of both sexes who consumed n-3 PUFA-enriched hen eggs (two eggs per day, for three weeks, total of approximately 407 mg/day n-3 PUFAs) or regular eggs (two eggs per day for three weeks, total of approximately 75 mg/day n-3 PUFAs) participated in this study. Skin microvascular endothelium-independent and endothelium-dependent vasodilation were assessed by laser Doppler flowmetry. Serum lipid profile and content of free fatty acids, markers of leukocyte activation, biochemical parameters of oxidative stress, as well as antioxidative enzymes serum activity were measured before and after respective dietary protocol. The results of this study revealed significant differences in the markers of leukocyte activation (such as CD11a/LFA-1) and antioxidative defense, which are related to increased intake of n-3 PUFAs, providing the evidence that consumption of nutritionally enriched hen eggs may affect physiological processes related to oxidative balance. The absence of significant changes in microvascular reactivity following supplementation with a low-intermediate dose of n-3 PUFAs, unlike in our previous studies where functional eggs contained ~1 g of n-3 PUFA, suggests the existence of a dose-dependent effect.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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