Safety and efficacy of photobiomodulation therapy in oncology: A systematic review
Bensadoun RJ, Epstein JB, Nair RG, Barasch A, Raber-Durlacher JE, Migliorati C, Genot-Klastersky MT, Treister N, Arany P, Lodewijckx J, Robijns J, World Association for Laser Therapy (WALT)
Cancer medicine · 73 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People, plus animal or lab work
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2020-10-26 · Cancer Med · vol. 9 · issue 22 · pp. 8279–8300
- Publisher
- Wiley
- Cited
- 114 citations · more than 92% of similar papers · 2.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 102 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Laser Applications in Dentistry and Medicine · Photodynamic Therapy Research Studies · Oral health in cancer treatment
- Keywords
- Medicine, Clinical trial, Systematic review, MEDLINE, Meta-analysis, In vivo, Cancer, Oncology, Head and neck cancer, Adverse effect, Internal medicine, Intensive care medicine, Biotechnology
- MeSH
- animals, humans, neoplasms, treatment outcome, tumor burden, cell differentiation, cell proliferation, low-level light therapy
11 authors
From FR, US, AU, NL, BE
- René‐Jean Bensadoun · correspondingCentre de Haute Energie
- Joel Brian EpsteinCity of Hope; Sinai Health System
- RAJ G. NAIRGriffith University; Queensland Health; Gold Coast Hospital; Gold Coast Health
- Andrei BaraschCambridge Health Alliance
- Judith E. Raber‐DurlacherAcademic Center for Dentistry Amsterdam; Amsterdam University Medical Centers; Amsterdam University of Applied Sciences; Vrije Universiteit Amsterdam; University of Amsterdam
- Cesar Augusto MiglioratiUniversity of Florida
Abstract
We performed a systematic review of the current literature addressing the safety and efficacy of photobiomodulation therapy (PBMT) in cancer patients. In this systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. In vitro, in vivo, and clinical studies, which investigated the effect of PBMT on cell proliferation/differentiation, tumor growth, recurrence rate, and/or overall survival were included. The Medline/PubMed, EMBASE, and Scopus databases were searched through April 2020. A total of 67 studies met the inclusion criteria with 43 in vitro, 15 in vivo, and 9 clinical studies identified. In vitro studies investigating the effect of PBMT on a diverse range of cancer cell lines demonstrated conflicting results. This could be due to the differences in used parameters and the frequency of PBM applications. In vivo studies and clinical trials with a follow-up period demonstrated that PBMT is safe with regards to tumor growth and patient advantage in the prevention and treatment of specific cancer therapy-related complications. Current human studies, supported by most animal studies, show safety with PBMT using currently recommended clinical parameters, including in Head & Neck cancer (HNC) in the area of PBMT exposure. A significant and growing literature indicates that PBMT is safe and effective, and may even offer a benefit in patient overall survival. Nevertheless, continuing research is indicated to improve understanding and provide further elucidation of remaining questions regarding PBM use in oncology.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.