Distinct contributions of skin and core temperatures to flow-mediated dilation of the brachial artery following passive heating
Coombs GB, Tremblay JC, Shkredova DA, Carr JMJR, Wakeham DJ, Patrician A, Ainslie PN
Journal of applied physiology (Bethesda, Md. : 1985) · 22 citations
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Government of Canada
- Government
- Canada Research Chairs
- Government
- Natural Sciences and Engineering Research Council of Canada
- Government
- Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada
- Grants
- Government of Canada (F14-04752); Canada Research Chairs (F16-02768); Natural Sciences and Engineering Research Council of Canada (F14-04752)
Based on 4 listed funder(s).
Publication
- Published
- 2020-10-29 · J Appl Physiol (1985) · vol. 130 · issue 1 · pp. 149–159
- Publisher
- American Physiological Society
- Cited
- 26 citations · more than 82% of similar papers · 1.5× the field average
- References
- 65 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Thermoregulation and physiological responses · Heart Rate Variability and Autonomic Control · Infrared Thermography in Medicine
- Keywords
- Brachial artery, Medicine, Hemodynamics, Core (optical fiber), Core temperature, Skin temperature, Heat stress, Dilation (metric space), Thermoregulation, Cardiology, Peripheral, Shear stress, Artery, Internal medicine, Materials science, Biomedical engineering, Blood pressure, Biology
- MeSH
- brachial artery, endothelium, vascular, humans, blood flow velocity, hand strength, dilatation, heating, temperature, regional blood flow, vasodilation, stress, mechanical, male
7 authors
From CA, NL, GB
- Geoff B. Coombs · correspondingUniversity of British Columbia; University of British Columbia, Okanagan Campus; Okanagan University College
- Joshua C. TremblayUniversity of British Columbia; University of British Columbia, Okanagan Campus; Okanagan University College
- Daria A. ShkredovaUniversity of British Columbia; Radboud University Nijmegen; Radboud University Medical Center; University of British Columbia, Okanagan Campus; Okanagan University College
- Jay M. J. R. CarrUniversity of British Columbia; University of British Columbia, Okanagan Campus; Okanagan University College
- Denis J. WakehamCardiff Metropolitan University
- Alexander PatricianUniversity of British Columbia; University of British Columbia, Okanagan Campus; Okanagan University College
Abstract
We measured acute vascular responses to heat stress to examine the hypothesis that macrovascular endothelial-dependent dilation is improved in a shear-dependent manner, which is further modified by skin temperature. Twelve healthy males performed whole body heating (+1.3°C esophageal temperature), bilateral forearm heating (∼38°C skin temperature), and a time-matched (∼60 min) control condition on separate days in a counterbalanced order. Bilateral assessments of blood flow and brachial artery flow-mediated dilation (FMD) were performed before and 10 min after each condition with duplex Doppler ultrasound. To isolate the influence of shear stress, a pneumatic cuff was inflated (∼90 mmHg) around the right forearm during each condition to attenuate heat-induced rises in blood flow and shear stress. After forearm heating, FMD increased [cuffed: 4.7 (2.9)% to 6.8 (1.5)% and noncuffed: 5.1 (2.8)% to 6.4 (2.6)%] in both arms (time P P P = 0.03). Multiple linear regression (adjusted R2 = 0.421 P = 0.003) revealed that changes in esophageal temperature, skin temperatures, and heart rate explained the majority of the variance in this model (34%, 31%, and 21%, respectively). Our findings indicate that, in addition to shear stress, skin and core temperatures are likely important contributors to passive heating-induced vascular adaptations.NEW & NOTEWORTHY The primary determinant of vascular adaptations to lifestyle interventions, such as exercise and heat therapy, is repeated elevations in vascular shear stress. Whether skin or core temperatures also modulate the vascular adaptation to acute heat exposure is unknown, likely due to difficulty in dissociating the thermal and hemodynamic responses to heat. We found that skin and core temperatures modify the acute vascular responses to passive heating irrespective of the magnitude of increase in shear stress.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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