Multiple Cryotherapy Attenuates Oxi-Inflammatory Response Following Skeletal Muscle Injury
Zembron-Lacny A, Morawin B, Wawrzyniak-Gramacka E, Gramacki J, Jarmuzek P, Kotlega D, Ziemann E
International journal of environmental research and public health · 18 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- This work was supported by the statutory funds from the University of Zielona Gora.
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-10-27 · Int J Environ Res Public Health · vol. 17 · issue 21 · p. 7855
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 33 citations · more than 86% of similar papers · 1.6× the field average
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Exercise and Physiological Responses · Spaceflight effects on biology · Sports injuries and prevention
- Keywords
- Skeletal muscle, Regeneration (biology), Hepatocyte growth factor, Vascular endothelial growth factor, Medicine, Growth factor, Internal medicine, Endocrinology, Neurotrophic factors, Biology, VEGF receptors, Cell biology
- MeSH
- muscle, skeletal, humans, athletic injuries, inflammation, reactive nitrogen species, reactive oxygen species, exercise, cryotherapy, sports medicine, oxidative stress, adult, young adult, athletes
7 authors
From PL
- Agnieszka Zembroń-Łacny · correspondingUniversity of Zielona Góra
- Barbara MorawinUniversity of Zielona Góra
- Edyta Wawrzyniak-GramackaUniversity of Zielona Góra
- J. GramackiUniversity of Zielona Góra
- Paweł JarmużekUniversity of Zielona Góra
- Dariusz KotlęgaState Higher Vocational School in Głogów; Pomeranian Medical University
Abstract
The oxi-inflammatory response is part of the natural process mobilizing leukocytes and satellite cells that contribute to clearance and regeneration of damaged muscle tissue. In sports medicine, a number of post-injury recovery strategies, such as whole-body cryotherapy (WBC), are used to improve skeletal muscle regeneration often without scientific evidence of their benefits. The study was designed to assess the impact of WBC on circulating mediators of skeletal muscle regeneration. Twenty elite athletes were randomized to WBC group (3-min exposure to -120 °C, twice a day for 7 days) and control group. Blood samples were collected before the first WBC session and 1 day after the last cryotherapy exposure. WBC did not affect the indirect markers of muscle damage but significantly reduced the generation of reactive oxygen and nitrogen species (H2O2 and NO) as well as the concentrations of serum interleukin 1β (IL-1β) and C-reactive protein (CRP). The changes in circulating growth factors, hepatocyte growth factor (HGF), insulin-like growth factor (IGF-1), platelet-derived growth factor (PDGFBB), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF), were also reduced by WBC exposure. The study demonstrated that WBC attenuates the cascade of injury-repair-regeneration of skeletal muscles whereby it may delay skeletal muscle regeneration.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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