The effects of Canola oil on cardiovascular risk factors: A systematic review and meta-analysis with dose-response analysis of controlled clinical trials
Amiri M, Raeisi-Dehkordi H, Sarrafzadegan N, Forbes SC, Salehi-Abargouei A
Nutrition, metabolism, and cardiovascular diseases : NMCD · 34 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Shahid Sadoughi University of Medical Sciences
Based on 1 listed funder(s).
Publication
- Published
- 2020-06-18 · Nutr Metab Cardiovasc Dis · vol. 30 · issue 12 · pp. 2133–2145
- Publisher
- Elsevier BV
- Cited
- 47 citations · more than 71% of similar papers · 1.1× the field average
- References
- 121 works
- Access
- Paywalled
- Research areas
- Fatty Acid Research and Health · Coconut Research and Applications · Edible Oils Quality and Analysis
- Keywords
- Meta-analysis, Canola, Medicine, Clinical trial, Internal medicine, Biology
- MeSH
- humans, cardiovascular diseases, treatment outcome, risk assessment, risk reduction behavior, energy intake, nutritive value, randomized controlled trials as topic, recommended dietary allowances, protective factors, rapeseed oil, diet, healthy, cardiometabolic risk factors
5 authors
From IR, CA
- Mojgan AmiriShahid Sadoughi University of Medical Sciences and Health Services
- Hamidreza Raeisi‐DehkordiShahid Sadoughi University of Medical Sciences and Health Services
- Nizal SarrafzadeganIsfahan University of Medical Sciences; University of British Columbia
- Scott C. ForbesBrandon University
- Amin Salehi‐Abargouei · correspondingShahid Sadoughi University of Medical Sciences and Health Services
Abstract
Background and aims
Canola oil (CO) is a plant-based oil with the potential to improve several cardiometabolic risk factors. We systematically reviewed controlled clinical trials investigating the effects of CO on lipid profiles, apo-lipoproteins, glycemic indices, inflammation, and blood pressure compared to other edible oils in adults.
Methods and results
Online databases were searched for articles up to January 2020. Forty-two articles met the inclusion criteria. CO significantly reduced total cholesterol (TC, -0.27 mmol/l, n = 37), low-density lipoprotein cholesterol (LDL-C, -0.23 mmol/l, n = 35), LDL-C to high-density lipoprotein cholesterol ratio (LDL/HDL, -0.21, n = 10), TC/HDL (-0.13, n = 15), apolipoprotein B (Apo B, -0.03 g/l, n = 14), and Apo B/Apo A-1 (-0.02, n = 6) compared to other edible oils (P < 0.05). Compared to olive oil, CO decreased TC (-0.23 mmol/l, n = 9), LDL-C (-0.17 mmol/l, n = 9), LDL/HDL (-0.39, n = 2), and triglycerides in VLDL (VLDL-TG, -0.10 mmol/l, n = 2) (P < 0.05). Compared to sunflower oil, CO improved LDL-C (-0.14 mmol/l, n = 11), and LDL/HDL (-0.30, n = 3) (P < 0.05). In comparison with saturated fats, CO improved TC (-0.59 mmol/l, n = 11), TG (-0.08 mmol/l, n = 11), LDL-C (-0.49 mmol/l, n = 10), TC/HDL (-0.29, n = 5), and Apo B (-0.09 g/l, n = 4) (P < 0.05). Based on the nonlinear dose-response curve, replacing CO with ~15% of total caloric intake provided the greatest benefits.
Conclusion
CO significantly improved different cardiometabolic risk factors compared to other edible oils. Further well-designed clinical trials are warranted to confirm the dose-response associations.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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