Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis
Pereira M, Dantas Damascena A, Galvão Azevedo LM, de Almeida Oliveira T, da Mota Santana J
Critical reviews in food science and nutrition · 266 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-11-04 · Crit Rev Food Sci Nutr · vol. 62 · issue 5 · pp. 1308–1316
- Publisher
- Taylor & Francis
- Cited
- 477 citations · more than 100% of similar papers · 23.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Paywalled
- Research areas
- Vitamin D Research Studies · COVID-19 Clinical Research Studies · Vitamin C and Antioxidants Research
- Keywords
- Medicine, vitamin D deficiency, Coronavirus disease 2019 (COVID-19), Meta-analysis, Vitamin D and neurology, Observational study, Internal medicine, Vitamin, Web of science, Disease, Gastroenterology, Pediatrics, Infectious disease (medical specialty)
- MeSH
- humans, vitamin d deficiency, vitamins, vitamin d, adult, aged, covid-19, sars-cov-2
5 authors
From BR
- Marcos Emanoel Pereira · correspondingUniversidade Federal da Bahia
- Alialdo Dantas DamascenaUniversidade Federal do Oeste da Bahia
- Laylla Mirella Galvão AzevêdoUniversidade Federal do Oeste da Bahia
- Tarcio de Almeida OliveiraUniversidade Federal da Bahia
- Jerusa da Mota SantanaUniversidade Federal da Bahia
Abstract
There is still limited evidence regarding the influence of vitamin D in people with COVID-19. In this systematic review and meta-analysis, we analyze the association between vitamin D deficiency and COVID-19 severity, via an analysis of the prevalence of vitamin D deficiency and insufficiency in people with the disease. Five online databases-Embase, PubMed, Scopus, Web of Science, ScienceDirect and pre-print Medrevix were searched. The inclusion criteria were observational studies measuring serum vitamin D in adult and elderly subjects with COVID-19. The main outcome was the prevalence of vitamin D deficiency in severe cases of COVID-19. We carried out a meta-analysis with random effect measures. We identified 1542 articles and selected 27. Vitamin D deficiency was not associated with a higher chance of infection by COVID-19 (OR = 1.35; 95% CI = 0.80-1.88), but we identified that severe cases of COVID-19 present 64% (OR = 1.64; 95% CI = 1.30-2.09) more vitamin D deficiency compared with mild cases. A vitamin D concentration insufficiency increased hospitalization (OR = 1.81, 95% CI = 1.41-2.21) and mortality from COVID-19 (OR = 1.82, 95% CI = 1.06-2.58). We observed a positive association between vitamin D deficiency and the severity of the disease.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.