Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection
Hernández JL, Nan D, Fernandez-Ayala M, García-Unzueta M, Hernández-Hernández MA, López-Hoyos M, Muñoz-Cacho P, Olmos JM, Gutiérrez-Cuadra M, Ruiz-Cubillán JJ, Crespo J, Martínez-Taboada VM
The Journal of clinical endocrinology and metabolism · 175 citations
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Ministerio de Economía y Competitividad
- Government
- Instituto de Salud Carlos III
- Grants
- Instituto de Salud Carlos III (PI18/00762)
Based on 2 listed funder(s).
Publication
- Published
- 2020-10-27 · J Clin Endocrinol Metab · vol. 106 · issue 3 · pp. e1343–e1353
- Publisher
- Oxford University Press
- Cited
- 286 citations · more than 100% of similar papers · 33.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · COVID-19 Clinical Research Studies · Vitamin C and Antioxidants Research
- Keywords
- Medicine, Vitamin D and neurology, Internal medicine, vitamin D deficiency, Ferritin, Intensive care unit, Gastroenterology, Population, Mechanical ventilation, Coronavirus disease 2019 (COVID-19), Surrogate endpoint, Case-control study, Disease, Infectious disease (medical specialty)
- MeSH
- humans, vitamin d deficiency, vitamin d, prognosis, respiration, artificial, hospitalization, length of stay, severity of illness index, mortality, hospital mortality, case-control studies, retrospective studies, aged, middle aged, intensive care units, spain, female, male, covid-19, sars-cov-2
12 authors
From ES
- José L. Hernández · correspondingUniversidad de Cantabria; Marqués de Valdecilla University Hospital; Instituto de Investigación Marqués de Valdecilla
- Daniel NanUniversidad de Cantabria; Marqués de Valdecilla University Hospital; Instituto de Investigación Marqués de Valdecilla
- Marta Fernández‐AyalaMarqués de Valdecilla University Hospital; Instituto de Investigación Marqués de Valdecilla
- Mayte García-UnzuetaMarqués de Valdecilla University Hospital; Instituto de Investigación Marqués de Valdecilla
- Miguel A. Hernández‐HernándezMarqués de Valdecilla University Hospital; Instituto de Investigación Marqués de Valdecilla
- Marcos López‐HoyosMarqués de Valdecilla University Hospital; Instituto de Investigación Marqués de Valdecilla
Abstract
Background
The role of vitamin D status in COVID-19 patients is a matter of debate.
Objectives
To assess serum 25-hydroxyvitamin D (25OHD) levels in hospitalized patients with COVID-19 and to analyze the possible influence of vitamin D status on disease severity.
Methods
Retrospective case-control study of 216 COVID-19 patients and 197 population-based controls. Serum 25OHD levels were measured in both groups. The association of serum 25OHD levels with COVID-19 severity (admission to the intensive care unit, requirements for mechanical ventilation, or mortality) was also evaluated.
Results
Of the 216 patients, 19 were on vitamin D supplements and were analyzed separately. In COVID-19 patients, mean ± standard deviation 25OHD levels were 13.8 ± 7.2 ng/mL, compared with 20.9 ± 7.4 ng/mL in controls (P < .0001). 25OHD values were lower in men than in women. Vitamin D deficiency was found in 82.2% of COVID-19 cases and 47.2% of population-based controls (P < .0001). 25OHD inversely correlates with serum ferritin (P = .013) and D-dimer levels (P = .027). Vitamin D-deficient COVID-19 patients had a greater prevalence of hypertension and cardiovascular diseases, raised serum ferritin and troponin levels, as well as a longer length of hospital stay than those with serum 25OHD levels ≥20 ng/mL. No causal relationship was found between vitamin D deficiency and COVID-19 severity as a combined endpoint or as its separate components.
Conclusions
25OHD levels are lower in hospitalized COVID-19 patients than in population-based controls and these patients had a higher prevalence of deficiency. We did not find any relationship between vitamin D concentrations or vitamin deficiency and the severity of the disease.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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