Funded in part by Eli Lilly and Company, Pfizer, Novartis, Sanofi, Academy of Nutrition and Dietetics, Meat and Livestock Australia, Servier, H. Lundbeck A/S, Woolworths Group, Allergan, Oxford University Press, Cilag
Ultraprocessed food and chronic noncommunicable diseases: A systematic review and meta-analysis of 43 observational studies
Lane MM, Davis JA, Beattie S, Gómez-Donoso C, Loughman A, O'Neil A, Jacka F, Berk M, Page R, Marx W, Rocks T
Obesity reviews : an official journal of the International Association for the Study of Obesity · 406 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- U.S. Department of Health and Human Services
- Nonprofit
- American Epilepsy Society
- Nonprofit
- Falk Foundation
- Nonprofit
- Wilson Foundation
- Company
- Eli Lilly and Company
- Company
- Pfizer
- Company
- Novartis
- Company
- Sanofi
- Nonprofit
- Academy of Nutrition and Dietetics Foundation
- Nonprofit
- Geelong Region Medical Research Foundation
- Nonprofit
- PA Research Foundation
- University or hospital
- Cooperative Research Centre for Living with Autism
- University or hospital
- Children’s Hospital of Wisconsin Research Institute
- Nonprofit
- Jack Brockhoff Foundation
- Government
- Department of Health and Human Services, State Government of Victoria
- Nonprofit
- David and Elaine Potter Foundation
- Nonprofit
- Simons Foundation Autism Research Initiative
- Government
- Australian Government
- Industry group
- Academy of Nutrition and Dietetics
- University or hospital
- Bond University
- University or hospital
- University of Oxford
- Government
- European GNSS Agency
- Nonprofit
- Multiple Sclerosis Australia
- Nonprofit
- Australian Academy of Science
- Nonprofit
- National Heart Foundation of Australia
- Nonprofit
- Australian Rotary Health
- Nonprofit
- Ian Potter Foundation
- Industry group
- Meat and Livestock Australia
- Nonprofit
- Epilepsy Society of Australia
- Nonprofit
- Australian and New Zealand College of Anaesthetists
- Nonprofit
- Beyond Blue
- University or hospital
- La Trobe University
- University or hospital
- University of New South Wales
- University or hospital
- University of Technology Sydney
- University or hospital
- Deakin University
- University or hospital
- RMIT University
- University or hospital
- University of Melbourne
- University or hospital
- James Cook University
- University or hospital
- University of Southern Queensland
- University or hospital
- University of the Sunshine Coast
- Government
- Fonds De La Recherche Scientifique - FNRS
- University or hospital
- Universidad de Navarra
- Company
- Servier
- University or hospital
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Company
- H. Lundbeck A/S
- Nonprofit
- Fernwood Foundation
- Nonprofit
- Epilepsy Society
- Company
- Woolworths Group
- Nonprofit
- Barwon Health Foundation
- Government
- City of Greater Geelong
- Government
- National Institutes of Health
- Company
- Allergan
- University or hospital
- Australian Centre for Microscopy and Microanalysis, University of Sydney
- Government
- Medical Research Council
- Government
- Australian Research Council
- Government
- National Health and Medical Research Council
- Nonprofit
- Cancer Council Queensland
- Government
- Instituto de Salud Carlos III
- Company
- Oxford University Press
- University or hospital
- Brain and Behaviour Research Institute, University of Wollongong
- Company
- Cilag
- Nonprofit
- Multiple Sclerosis Research Australia
- Grants
- University of Melbourne (1156072); National Health and Medical Research Council (101160); National Health and Medical Research Council (1156072); Deakin University (1059660); Instituto de Salud Carlos III (FI18/00073); National Heart Foundation of Australia (#101160); National Health and Medical Research Council (1059660)
Based on 62 listed funder(s).
Publication
- Published
- 2020-11-09 · Obes Rev · vol. 22 · issue 3 · p. e13146
- Publisher
- Wiley
- Cited
- 677 citations · more than 100% of similar papers · 17.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 126 works
- Access
- Free to read
- Research areas
- Consumer Attitudes and Food Labeling · Obesity, Physical Activity, Diet · Nutritional Studies and Diet
- Keywords
- Observational study, Meta-analysis, Medicine, Environmental health, Gerontology, Internal medicine
- MeSH
- humans, prospective studies, cross-sectional studies, food handling, food, adolescent, adult, child, observational studies as topic, noncommunicable diseases
11 authors
From AU, ES
- Melissa M. Lane · correspondingBarwon Health; Deakin University
- Jessica A. DavisBarwon Health; Deakin University
- Sally BeattieBarwon Health; St John of God Hospital
- Clara Gómez‐DonosoInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universidad de Navarra
- Amy LoughmanBarwon Health; Deakin University
- Adrienne E O'NeilBarwon Health; Deakin University
Abstract
This systematic review and meta-analysis investigated the association between consumption of ultraprocessed food and noncommunicable disease risk, morbidity and mortality. Forty-three observational studies were included (N = 891,723): 21 cross-sectional, 19 prospective, two case-control and one conducted both a prospective and cross-sectional analysis. Meta-analysis demonstrated consumption of ultraprocessed food was associated with increased risk of overweight (odds ratio: 1.36; 95% confidence interval [CI], 1.23-1.51; P < 0.001), obesity (odds ratio: 1.51; 95% CI, 1.34-1.70; P < 0.001), abdominal obesity (odds ratio: 1.49; 95% CI, 1.34-1.66; P < 0.0001), all-cause mortality (hazard ratio: 1.28; 95% CI, 1.11-1.48; P = 0.001), metabolic syndrome (odds ratio: 1.81; 95% CI, 1.12-2.93; P = 0.015) and depression in adults (hazard ratio: 1.22; 95% CI, 1.16-1.28, P < 0.001) as well as wheezing (odds ratio: 1.40; 95% CI, 1.27-1.55; P < 0.001) but not asthma in adolescents (odds ratio: 1.20; 95% CI, 0.99-1.46; P = 0.065). In addition, consumption of ultraprocessed food was associated with cardiometabolic diseases, frailty, irritable bowel syndrome, functional dyspepsia and cancer (breast and overall) in adults while also being associated with metabolic syndrome in adolescents and dyslipidaemia in children. Although links between ultraprocessed food consumption and some intermediate risk factors in adults were also highlighted, further studies are required to more clearly define associations in children and adolescents. STUDY REGISTRATION: Prospero ID: CRD42020176752.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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